The ability to capture joint kinematics in outside-laboratory environments is clinically relevant. In order to estimate kinematics, inertial measurement units can be attached to body segments and their absolute orientations can be estimated. However, the heading part of such orientation estimates is known to drift over time, resulting in drifting joint kinematics. This study proposes a novel joint kinematic estimation method that tightly incorporates the connection between adjacent segments within a sensor fusion algorithm, to obtain drift-free joint kinematics. Drift in the joint kinematics is eliminated solely by utilizing common information in the accelerometer and gyroscope measurements of sensors placed on connecting segments. Both an optimization-based smoothing and a filtering approach were implemented. Validity was assessed on a robotic manipulator under varying measurement durations and movement excitations. Standard deviations of the estimated relative sensor orientations were below 0.89 • in an optimization-based smoothing implementation for all robot trials. The filtering implementation yielded similar results after convergence. The method is proven to be applicable in biomechanics, with a prolonged gait trial of 7 minutes on 11 healthy subjects. Three-dimensional knee joint angles were estimated, with mean RMS errors of 2.14 • , 1.85 • , 3.66 • in an optimization-based smoothing implementation and mean RMS errors of 3.08 • , 2.42 • , 4.47 • in a filtering implementation, with respect to a golden standard optical motion capture reference system. Tommy Verbeerst received the M.Sc. degree in electrical engineering from KHBO, Ostend, Belgium, in 2008. Since 2013, he has been working with KU Leuven and UC Vives. He is affiliated with the Department of Electrical Engineering (ESAT), KU Leuven Campus Bruges, Belgium. His current research interest includes the fields of engineering education, robotics, and machine-vision. Mark Versteyhe received the M.Sc. degree in mechanical engineering and the Ph.D. degree in applied sciences, from KU Leuven in 1995 and 2000, respetively.He has worked 16 years in industry in various functions linked to research and innovation. Since October 2016, he has been a Professor with KU Leuven's Faculty of Engineering Technology, Technology Campus Brugge, where he co-ordinates the research effort on connected mechatronics. His research focus lies in studying and applying the holistic paradigm of mechatronic system design. His special interest goes to "Dependability" which encompasses reliabilityavailability-robustness and security of a system and "Distributed Systems" which are treated as a complex ecosystem of machines and humans that are connected within the Industry 4.0 paradigm shift.Kurt Claeys received the M.Sc. degree in musculoskeletal rehabilitation sciences and physiotherapy from the University of Ghent, Belgium, in 1993, and the Ph.D. degree in orthopedic manual therapist from the IRSK-WINGS institute Ieper, Belgium, in 2005, and the Ph.D. degree from KU Leuven, Belgium,...