Soft Tissue Augmentation

Elson, Melvin L.

doi:10.1111/j.1524-4725.1995.tb00252.x

Cited by 43 publications

(35 citation statements)

References 13 publications

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“…The ideal filling substance for soft-tissue augmentation should be biocompatible, nonantigenic, nonpyrogenic, noninflammatory, nontoxic, easy to use, stable after injection, nonmigratory, long-lasting but reabsorbable, natural looking, and not too expensive. 9,10 A ubiquitous component of all mammalian connective tissue, hyaluronic acid (Hyaluronan), is a naturally occurring polysaccharide, in the same chemical and molecular composition in all species; in the intercellular matrix of dermal layers of the skin of all species; therefore, it is highly biocompatible to use animal sources in humans without creating foreign body reactions. [11][12][13] The material used in this study is based on hyaluronic acid, which has already been used in its native form as an implant for more than 20 y and in millions of individuals without causing adverse reactions.…”

Section: Discussionmentioning

confidence: 99%

Human glans penis augmentation using injectable hyaluronic acid gel

et al. 2003

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Although augmentation phalloplasty is not an established procedure, some patients still need enlargement of their penis. Current penile augmentation is girth enhancement of penile body by dermofat graft. We performed this study to identify the efficacy and the patient's satisfaction of human glans penis augmentation with injectable hyaluronic acid gel. In 100 patients of subjective small penis (Group I) and 87 patients of small glans after dermofat graft (Group II), 2 cm 3 of hyaluronic acid gel was injected into the glans penis, subcutaneously. At 1 y after injection, changes of glandular diameter were measured by tapeline. Patient's visual estimation of glandular size (Gr 0-4) and patient's satisfaction (Grade (Gr) 0-4) were evaluated, respectively. Any adverse reactions were also evaluated. The mean age of patients was 42.2 (30-70) y in Group I and 42.13 (28-61) y in Group II. The maximal glandular circumference was significantly increased compared to basal circumference of 9.13 7 0.64 cm in Group I (Po0.01) and 9.49 7 1.05 cm in Group II (Po0.01) at 1 y after injection. Net increase of maximal glandular circumference after glans augmentation was 14.93 7 0.80 mm in Group I and 14.78 7 0.89 mm in Group II. In patient's visual estimation, more than 50% of injected volume was maintained in 95% of Group 1 and 100% of Group II. The percentage of postoperative satisfaction (Gr 4, 5) was 77% in Group 1 and 69% in Group II. There was no abnormal reaction in area feeling, texture, and color. In most cases, initial discoloration by glandular swelling recovered to normal within 2 weeks. There were no signs of inflammation and no serious adverse reactions in all cases. These results suggest that injectable hyaluronic acid gel is a safe and effective material for augmentation of glans penis.

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Section: Discussionmentioning

confidence: 99%

Human glans penis augmentation using injectable hyaluronic acid gel

et al. 2003

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“…The ideal filling substance for soft-tissue augmentation should be biocompatible, nonantigenic, nonpyrogenic, noninflammatory, nontoxic, easy to use, stable after injection, nonmigratory, long lasting but reabsorbable, natural looking and not too expensive. 11,12 A ubiquitous component of all mammalian connective tissue, HA (hyaluronan) is a naturally occurring polysaccharide, in the same chemical and molecular composition in all species; in the intercellular matrix of dermal layers of the skin of all species, therefore, it is highly biocompatible to use animal sources in humans without creating foreign body reactions. [13][14][15] The material used in this study is based on HA, which has already been used in its native form as an implant for more than 20 y and in millions of individuals without causing adverse reactions.…”

Section: Discussionmentioning

confidence: 99%

Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation

et al. 2004

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The main limitation of medical treatment for premature ejaculation is recurrence after withdrawal of medication. We evaluated the effect of glans penis augmentation using injectable hyaluronic acid (HA) gel for the treatment of premature ejaculation via blocking accessibility of tactile stimuli to nerve receptors. In 139 patients of premature ejaculation, dorsal neurectomy (Group I, n ¼ 25), dorsal neurectomy with glandular augmentation (Group II, n ¼ 49) and glandular augmentation (Group III, n ¼ 65) were carried out, respectively. Two branches of dorsal nerve preserving that of midline were cut at 2 cm proximal to coronal sulcus. For glandular augmentation, 2 cc of HA was injected into the glans penis, subcutaneously. At 6 months after each procedure, changes of glandular circumference were measured by tapeline in Groups II and III. In each groups, ejaculation time, patient's satisfaction and partner's satisfaction were also assessed. There was no significant difference in preoperative ejaculation time among three groups. Preoperative ejaculation times were 89.2740.29, 101.54759.42 and 96.5752.32 s in Groups I, II and III, respectively. Postoperative ejaculation times were significantly increased to 235.6758.6, 324.247107.58 and 281.9793.2 s in Groups I, II and III, respectively (Po0.01). The percentage of postoperative satisfaction in both patient and his partner was 68% (17/25) and 44% (7/16) in Group I, 80% (39/49) and 66% (25/38) in Group II and 75% (49/65) and 62% (32/52) in Group III, respectively. Maximal glandular girth was significantly increased from 9.1670.59 to 10.9570.4 cm in Group II and 8.9570.54 to 11.6770.71 cm in Group III, respectively. These results suggest that glandular augmentation with injectable HA gel is a safe and effective modality to reduce sensory of glans penis. Long-term follow-up for residual volume and efficacy should be requested to establish its precise therapeutic potentials in premature ejaculation.

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“…7,8 A ubiquitous component of all mammalian connective tissue, hyaluronic acid (Hyaluronan) is a naturally occurring polysaccharide of the same chemical and molecular composition in all species in the intercellular matrix of dermal layers of the skin of all species; therefore, it is highly biocompatible to use animal sources in humans without creating foreign body reactions. [9][10][11] The hyaluronic acid matrix has an enormous ability to bind water (water content greater than 99%) and form hydrated polymers of high viscosity.…”

Section: Discussionmentioning

confidence: 99%

Augmentation of glans penis using injectable hyaluronic acid gel

et al. 2003

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Recently, injectable hyaluronic acid gel has been widely used in soft-tissue augmentation. We performed this study to identify the feasibility of hyaluronic acid gel for the augmentation of the glans penis. In experiment I, 0.2 cm 3 of hyaluronic acid gel (HA) was injected into the dermis of the glans penis of 25 New Zealand white rabbits via a 30 G needle. At 3, 7, 14, 30, and 90 days after injection, histological changes of glans were studied, respectively. In experiment II, 0.5 cm 3 of HA was injected into the dermis of the glans penis of 14 Beagle dogs via a 27 G needle. At 6 months after injection, histological changes of the glans penis were also evaluated. At the time of autopsy, the lung, liver, and spleen were studied for systemic adverse reaction in each separate experiment. In experiment I, various sized cavities filled with amorphous basophilic materials were noted in the lamina propria and corpus spongiosum of the glans penis. All implants were positively stained on alcian blue. The intensity decreased in a time-dependent manner. Until 14 days, minimal inflammatory reactions were noted, but no signs of inflammation were identified at 90 days. With the gradual decrease of inflammation, fibrosis and deposition of collagen were noted. In experiment II, implants were well maintained at 6 months after injection in the lamina propria. Grade 1 of the inflammatory reaction was noted in one case. In both the experiments, all the specimens were free from any foreign body reaction and systemic adverse reactions. In conclusion, these results suggest that hyaluronic acid gel can be easily injected into the lamina propria of the glans penis and reside until 6 months. Injectable hyaluronic acid gel has a potential as a new bioimplant for the augmentation of the glans penis.

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Soft Tissue Augmentation

Abstract: With the understanding of the role of soft tissue augmentation in the overall treatment of the aging face as well as risk factors and ways to minimize the side effects, dermatologic surgeons can reach the goal of effectively treating patients with these materials.

Cited by 43 publications

References 13 publications

Human glans penis augmentation using injectable hyaluronic acid gel

Human glans penis augmentation using injectable hyaluronic acid gel

Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation

Augmentation of glans penis using injectable hyaluronic acid gel

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