Soft Tissue Myoepithelial Carcinoma in a Child: Case Report

Ayed, Faten Fedhila Ben; Khomsi, W. Douira; Rhayem, S.; Doghri, Raoudha; Khémiri, M.; Barsaoui, Sihem

doi:10.1097/mph.0000000000000518

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…The tumor is positive for broad-spectrum keratins (93-100%), including AE1/AE3 , PAN-K , CAM5.2 , and/or EMA (17-79%) 13 . p63 is positive is a subset of tumors 7 . SOX10, while present in 80% of myoepithelial neoplasms, is only detected in 30% of cases of myoepithelial carcinomas 13,17 .…”

Section: Discussionmentioning

confidence: 99%

“…Although malignant myoepithelial neoplasms contain the label “carcinoma,” they are not derived from recognizable epithelium, and they may show heterologous differentiation and express both stromal and epithelial cytokeratin markers 4 . When evaluating painless soft-tissue lesions, accelerated growth, large size, and location deep to deep fascia (with potential fixation to underlying bone) 5,6 may generate suspicion for malignancy 7 . Magnetic resonance imaging (MRI) can be used for preoperative diagnostic planning 6,7 , but moderate-to-severe cellular atypia is the only definitive diagnostic criterion for malignancy 8 .…”

mentioning

confidence: 99%

“…When evaluating painless softtissue lesions, accelerated growth, large size, and location deep to deep fascia (with potential fixation to underlying bone) 5,6 may generate suspicion for malignancy 7 . Magnetic resonance imaging (MRI) can be used for preoperative diagnostic planning 6,7 , but moderate-to-severe cellular atypia is the only definitive diagnostic criterion for malignancy 8 . EWSR1 (Ewing Sarcoma breakpoint region 1: 22q12.2) gene arrangement and immunohistochemical (IHC) analysis positive for cytokeratins, S100, GFAP, and/or calponin are also reported [9][10][11] .…”

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confidence: 99%

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Myoepithelial Carcinoma of Soft Tissue

Richards,

Vijayakumar,

Braun

et al. 2024

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Case: A 40-year-old man was evaluated for a painful mass on his right calf, and a 36-year-old woman presented with a painless mass on her right foot. Final pathology revealed marked nuclear atypia and positivity for S100/SOX10 and AE1/AE3 confirming diagnoses of myoepithelial carcinoma. Both patients underwent surgical resection and are without evidence of local recurrence or metastatic disease at 1-year follow-up. Conclusion: Soft-tissue tumors presenting in the extremities warrant careful evaluation and timely histopathologic diagnosis. Myoepithelial carcinomas are rare, aggressive tumors with a propensity for local recurrence and metastasis. Treatment of these tumors should be discussed by a multidisciplinary tumor team.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Myoepithelial Carcinoma of Soft Tissue

Richards,

Vijayakumar,

Braun

et al. 2024

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“…[1] The differential diagnosis of EMC may include the aggressive and rarely reported tumor myoepithelial carcinoma of soft tissue. [11] However, soft tissue myoepithelial carcinoma was excluded due to the following: Cellularity was not pronounced, sclerosis was extensive, necrosis was not identified, mitoses were rare, and the typical areas of EMC with prominent nodularity were present. [1] Unfortunately, we have not investigated NR4A3 rearrangement which is an effective adjunct in diagnosing EMC.…”

Section: Discussionmentioning

confidence: 99%

Extraskeletal myxoid chondrosarcoma of the leg in a child

et al. 2019

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Rationale: Extraskeletal myxoid chondrosarcoma is a slow-growing soft tissue tumor of adults with a propensity for local recurrence and eventual metastasis. Only 17 pediatric and adolescent cases have been reported. Patient concerns: Here we present an 11-year-old boy with a 3-year history of a slowly growing painless left leg mass. Magnetic resonance imaging of the lesion revealed a subfascial well-circumscribed lesion with intramuscular extension in the medial gastrocnemius muscle of the left leg. Diagnoses: He underwent wide local excision of the mass and the histomorphological and immunohistochemical findings were consistent with extraskeletal myxoid chondrosarcoma. Interventions: Possible radiotherapy was the further management plan. Outcomes: He was in good condition with no evidence of recurrence at 6 months postsurgery. Lessons: Although pediatric cases of extraskeletal myxoid chondrosarcoma were reported to be aggressive, the tumor in this case demonstrated indolent behavior. Furthermore, the tumor in this case showed primitive round cell foci which adds to a previous study that especially reported this morphology in pediatric cases.

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