Soft Tissue Plasmacytoma of the Orbit as Part of the Spectrum of Multiple Myeloma

Lazaridou, Marie-Noëlle; Micallef-Eynaud, P.; Hanna, Ivan T.

doi:10.1080/01676830601169122

Cited by 13 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Incidence of orbital myeloma is around 3%. 6 It occurs in the sixth to seventh decades and is more common in males. Multiple myeloma typically involves the posterior extraconal space of the orbit, and a key feature is a location in the superotemporal quadrant associated with bone erosion.…”

Section: Discussionmentioning

confidence: 99%

Orbital plasmacytoma as the presenting feature in multiple myeloma

Mani

Kasturi

Sravya

et al. 2020

European Journal of Ophthalmology

View full text Add to dashboard Cite

A 50-year-old female patient presented with protrusion of the left eye for 1 month. Examination showed abaxial proptosis, restriction of extraocular movements, and elevated intraocular pressure. Computed tomography of the orbits showed soft tissue enhancing lesion in the superolateral aspect of the left orbit with lytic lesions in calvarium. Fine needle aspiration cytology of the lesion revealed a diagnosis of plasmacytoma with positive CD138 and CD38 immunohistochemical stains. Erythrocyte sedimentation rate, C-reactive protein and serum lactate dehydrogenase were elevated. Serum protein electrophoresis revealed hypergammaglobulinemia, and bone marrow biopsy revealed 6% plasma cells. The patient was started on chemotherapy with bortezomib, dexamethasone and lenalidomide by the medical oncologist. Significant improvement in proptosis and extraocular movements noted on follow-up. Orbital myeloma may be the first manifestation of systemic disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Orbital plasmacytoma as the presenting feature in multiple myeloma

Mani

Kasturi

Sravya

et al. 2020

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…1 Orbital involvement by secondary plasmacytoma is rare and considered as worse prognosis for systemic morbidity. [2][3][4][5] We report a case refractory Ig G kappa MM with multiple relapses, bone fractures and renal dysfunction who presented with orbital lesions.…”

Section: Issn 0972-0200mentioning

confidence: 99%

Secondary Plasmacytoma of The Orbit In A Patient With Refractory Ig G Kappa Multiple Myeloma

Turaka¹

2014

Delhi Journal of Ophthalmology

View full text Add to dashboard Cite

Aim: To report the image findings and treatment response of orbital plasmacytoma in a patient with Durie-Salmon Stage IIIA recurrent refractory multiple myeloma (MM). Methods: A case report Results: A 52 year old woman with 2 years prior history of relapsed refractory Ig G kappa MM presented with exophthalmia, restricted motility and poor vision in left eye. Ocular examination revealed light perception vision with severe proptosis, moderate ophthalmoplegia, conjunctival chemosis and total retinal detachment in the left eye. CT and MRI of the orbits revealed 2 separate large masses in the superolateral orbit and apex of the left orbit, where were treated with orbital radiation of 20 Gy. She had improvement in the ocular symptoms with decrease in proptosis with no marked improvement in visual acuity. Despite of aggressive systemic chemotherapy she succumbed to death within 3 months due to distant metastatic lesions of MM. Conclusions: Plasmacytoma of the orbit is rare. Radiotherapy helps in improving the symptoms by decreasing the size of lesions thereby relieving the orbital pressure and provides better quality of life to patients with advanced systemic illness such as MM.

show abstract

“…1 Secondary orbital plasmacytomas have been reported to be a possible indication of multiple myeloma recurrence. 2,3 In the setting of secondary orbital plasmacytoma occurring as the presenting sign of recurrent multiple myeloma, the tumor can be significant, and has been reported to result Orbital Plasmacytoma Mimicking an Orbital Abscess in no-light-perception vision. 4 Rare presentations of orbital plasmacytomas include mimicking a chalazion, mimicking a lacrimal gland tumor, mimicking dacryocystitis, eyelid ecchymosis, angioedema-like eyelid edema, variable ptosis, fungating eyelid lesions, isolated extraocular muscle infiltration, orbital hemorrhage, Tolosa Hunt syndrome, or orbital cellulitis.…”

Section: Discussionmentioning

confidence: 98%

Orbital Plasmacytoma Mimicking an Orbital Abscess

Russell¹,

Seiff²

2017

Ophthalmic Plastic &Amp; Reconstructive Surgery

View full text Add to dashboard Cite

An 83-year-old male with a 15-month history of multiple myeloma presented with acute onset of swelling, redness, and pain around his right eye. CT scan was consistent with an orbital abscess. The patient was taken to the operating room for drainage of the orbital abscess. Abnormal tissue was encountered intraoperatively so biopsies were taken. His cultures grew only one colony of coagulase-negative Staphylococcus aureus. The histopathology from the biopsies showed a CD-138 positive plasma cell neoplasia consistent with a plasmacytoma. Plasmacytomas have been reported to present as orbital cellulitis and as abscesses in other locations in the body, but to our knowledge, this is the first case of a plasmacytoma presenting as an orbital abscess.

show abstract

Soft Tissue Plasmacytoma of the Orbit as Part of the Spectrum of Multiple Myeloma

Cited by 13 publications

References 7 publications

Orbital plasmacytoma as the presenting feature in multiple myeloma

Orbital plasmacytoma as the presenting feature in multiple myeloma

Secondary Plasmacytoma of The Orbit In A Patient With Refractory Ig G Kappa Multiple Myeloma

Orbital Plasmacytoma Mimicking an Orbital Abscess

Contact Info

Product

Resources

About