Soft tissue responses to hydroxylapatite particles of different shapes

Misiek, Dale J.; Kent, John N.; Carr, Ronald F.

doi:10.1016/s0278-2391(84)80025-7

Cited by 179 publications

(80 citation statements)

References 6 publications

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“…Experiments were repeated five times with similar results. Among these materials, hydroxyapatite has been reported by many authors to have excellent biocompatibility and a high hard-tissueforming ability [18][19][20][21][22] . Recently, a high surgical success rate and early postoperative recovery are demanded, but improvements in the surgical technique alone are insufficient to meet these demands.…”

Section: Discussionmentioning

confidence: 99%

Effects of Heat Treatment of Hydroxyapatite on Osteoblast Differentiation

Asami

Nakamura

Takeuchi

et al. 2008

J. Hard Tissue Biology.

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To develop hydroxyapatite that promotes early cure of postoperative tissue, we heat-treated hydroxyapatite and evaluated its pH-increasing effect and Ca release. We also evaluated the effect of heattreated hydroxyapatite on osteoblast differentiation. (1) No marked change was observed regarding the surface morphology or structure of heat-treated hydroxyapatite on SEM. (2) When hydroxyapatite was immersed in physiologic saline, the saline was made more alkaline by heat-treated than non-heat-treated hydroxyapatite. (3) When hydroxyapatite was immersed in physiologic saline, more Ca ions were released from heat-treated than non-heat-treated hydroxyapatite. (4) X-ray diffraction analysis showed a peak of CaO, which is considered to explain the Ca ion release, in heat-treated hydroxyapatite. (5) When osteoblasts were cultured with hydroxyapatite, heat-treated hydroxyapatite prevented the decrease in the number of alkaline phosphatasepositive osteoblasts in the presence of non-heat-treated hydroxyapatite. Thus, heat-treated hydroxyapatite was suggested to promote early cure of postoperative tissue. Detailed analysis of in vivo effects of heat-treated hydroxyapatite is anticipated to make its clinical application possible.

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Section: Discussionmentioning

confidence: 99%

Effects of Heat Treatment of Hydroxyapatite on Osteoblast Differentiation

Asami

Nakamura

Takeuchi

et al. 2008

J. Hard Tissue Biology.

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“…When materials are reduced to particles, surface area and subsequent interactions with tissues of the recipient sites are increased and therefore allow an amplification of the biological reaction. Because chemical composition [ 11, size [20], shape [20,21], and surface character [lo] of materials influence the nature and magnitude of the socalled foreign body reaction, it is important to study materials with comparability in these parameters. Goodman and co-workers [9] showed that small (10-100 pm) particles of PMMA stimulated a florid foreign body response composed of histiocytes and giant cells, similar to that seen at the interface of loose cemented implants in humans.…”

Section: Discussionmentioning

confidence: 99%

Tissue reactions to particles of bone‐substitute materials in intraosseous and heterotopic sites in rats: discrimination of osteoinduction, osteocompatibility, and inflammation

Eid

Zelicof

Perona

et al. 2001

Journal Orthopaedic Research

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Two rat models were used to characterize tissue-specific reactions to particles of bone-substitute materials: one for osteocompatibility in a healing tibial wound and the other in a heterotopic, subcutaneous site. Small, unicortical tibial wounds in rats healed spontaneously, beginning with the rapid proliferation of intramedullary woven bone. That temporary bone was resorbed by osteoclasts and finally, the cortical wound was healed with lamcllar bone and the medullary space was repopulated with marrow. When various particulate materials were implanted into fresh wounds, three types of reactions were observed. (1) Demineralized bone powder (DBP) and non-resorbable calcium phosphate (nrCP) were incorporated into the reactive medullary and cortical bone.(2) Polymethylmethacrylate (PMMA) particles were surrounded with a fibrous layer, but did not impair bone healing. (3) Polyethylene (PE) shards and resorbable calcium phosphates (rCPs) were inflammatory and inhibited osseous repair.Subcutaneous sites showed osteoinductive, fibrotic, or inflammatory responses to these materials. Only DBP induced endochondral osteogenesis subcutaneously. The nrCP evoked a fibrous reaction. In contrast, rCPs, PMMA, and PE shards generated inflammatory reactions with each particle being surrounded by fibrous tissue and large multinucleated giant cells.In conclusion, only DBP showed osteoinductive as well as osteocompatible properties. The nrCP was osteocompatible. The rCPs stimulated various degrees of inflammatory responses. PMMA was osteocompatible and did not interfere with the bone healing process. PE was not osteocompatible and generated foreign body reactions in both sites. Use of the two sites distinguishes osteoinductive, osteocompatible, and inflammatory properties of particles of bonc-substitute materials. 0

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“…Histologically, the calcium hydroxylapatite microspheres do not ''provide a scaffold for tissue infiltration consistent with the form of the surrounding tissue''. Because of little tissue ingrowth [16,43] and absence of granulation tissue, triamcinolone (KenalogÒ) injections into Radiance lumps will be ineffective and should be omitted. In some patients, however, Radiance microspheres may induce a kind of foreign body reaction -as demonstrated by one histological picture in the company's advertisement, which of course will react to intralesional corticosteroids.…”

Section: Calcium-hydroxylapatite Microspheresmentioning

confidence: 99%

Human Histology and Persistence of Various Injectable Filler Substances for Soft Tissue Augmentation

Lemperle

Morhenn

Charrier³

2003

Aesthetic Plastic Surgery

456

311

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Abstract. An increasing number of soft tissue filler substances have been introduced to the beauty market outside the U.S. which lack experimental and clinical data in support of their claim. Ten commercially available filler substances were examined for biocompatibility and durability: 0.1 cc of each substance was injected deep intradermally into the volar forearm of one of the authors and observed for clinical reaction and permanence. At 1, 3, 6, and 9 months the test sites were excised, histologically examined, and graded according to foreign body reactions classification. Collagen (Zyplast) was phagocytosed at 6 months and hyaluronic acid (Restylane) at 9 months. PMMA microspheres (Artecoll) had encapsulated with connective tissue, macrophages, and sporadic giant cells. Silicone oil (PMS 350) was clinically inconspicuous but dissipated into the tissue, causing a chronic foreign body reaction. Polylactic acid microspheres (New-Fill) induced a mild inflammatory response and had disappeared clinically at 4 months. Dextran microspheres (Reviderm intra) induced a pronounced foreign body reaction and had disappeared at 6 months. Polymethylacrylate particles (Dermalive) induced the lowest cellular reaction but had disappeared clinically at 6 months. Polyacrylamide (Aquamid) was well tolerated and remained palpable to a lessening degree over the entire testing period. Histologically, it dissipated more slowly and was kept in place through fine fibrous capsules. Polyvinylhydroxide microspheres suspended in acrylamide (Evolution) were well tolerated, slowly diminishing over 9 months. Calcium hydroxylapatite microspheres (Radiance FN) induced almost no foreign body reaction but were absorbed by the skin at 12 months.Host defense mechanisms react differently to the various filler materials, but all substances-resorbable or nonresorbable-appeared to be clinically and histologically safe, although all exhibit undesirable side effects. Since the mechanism of late inflammation or granuloma formation is still unknown, early histological findings are not useful in predicting possible late reactions to filler substances.

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Soft tissue responses to hydroxylapatite particles of different shapes

Cited by 179 publications

References 6 publications

Effects of Heat Treatment of Hydroxyapatite on Osteoblast Differentiation

Effects of Heat Treatment of Hydroxyapatite on Osteoblast Differentiation

Tissue reactions to particles of bone‐substitute materials in intraosseous and heterotopic sites in rats: discrimination of osteoinduction, osteocompatibility, and inflammation

Human Histology and Persistence of Various Injectable Filler Substances for Soft Tissue Augmentation

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