Soft-Tissue sarcoma in childhood and adolescence

Raney, R. Beverly

doi:10.1007/s11912-002-0004-4

Cited by 11 publications

(4 citation statements)

References 26 publications

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“…Rhabdomyosarcomas are treated primarily with chemotherapy. 1,2 The role of surgery is limited to initial biopsy, wide local excision (whenever clear margins are possible), and resection of residual disease. Radiotherapy in the form of external beam or brachytherapy is restricted to persistent or recurrent disease.…”

Section: Diagnostic Applicationsmentioning

confidence: 99%

“…The primary therapy for non-rhabdomyosarcomas is surgical resection, but adjuvant radiotherapy and chemotherapy are being used with increasing success. 1,3 Another major difference between these two categories is involvement of lymphatics. Rhabdomyosarcomas often involve the regional lymph nodes, indicating the importance of lymph node evaluation for staging.…”

Section: Diagnostic Applicationsmentioning

confidence: 99%

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Molecular Genetics of Pediatric Soft Tissue Tumors

Chang¹,

Shidham²

2003

The Journal of Molecular Diagnostics

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The application of molecular genetics to pediatric soft tissue tumors has grown tremendously over the last decade. It has resulted in the identification of novel genes that have provided us with an increased understanding of oncogenesis. Furthermore, these findings have identified diagnostic and potentially prognostic factors for patient management. Molecular diagnostic techniques, such as reverse transcription PCR (RT-PCR) and fluorescence in situ hybridization (FISH), have become important tools for evaluating pediatric soft tissue tumors. By detecting characteristic fusion genes, these techniques have greatly increased the diagnostic accuracy of histopathological classification. One of the exciting promises of the development of these molecular techniques is their ability to detect micrometastasis and minimal residual disease. Monitoring of minimal residual disease in pediatric soft tissue tumors by quantitative RT-PCR may provide important prognostic information. Furthermore, the potential development of targeted therapy based on the understanding of the molecular pathology of a specific soft tissue tumor may complement existing treatments and improve disease outcome.

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Section: Diagnostic Applicationsmentioning

confidence: 99%

Section: Diagnostic Applicationsmentioning

confidence: 99%

Molecular Genetics of Pediatric Soft Tissue Tumors

Chang¹,

Shidham²

2003

The Journal of Molecular Diagnostics

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“…Leukemia is the most common pediatric malignancy, accounting for approximately one-third of all cases, followed in order of decreasing frequency by brain tumors, lymphomas (Hodgkin's disease and non-Hodgkin's lymphoma), neuroblastoma, soft-tissue sarcomas (including rhabdomyosarcoma), kidney tumors (primarily Wilms' tumor), bone tumors (osteosarcoma and Ewing's sarcoma [EWS]), and retinoblastoma. [1][2][3][4][5][6][7] During the past 30 years, the prognosis for all types of childhood cancer has improved dramatically. Environmental and genetic factors are linked to an increased risk of cancer.…”

Section: Introductionmentioning

confidence: 99%

Molecular diagnosis of pediatric tumors

Mukherjee

Dutta

2017

Int J Mol Immuno Oncol.

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<p>Pediatric tumors are challenging in the context of best diagnosis, treatment, and prognosis. For tumors which have a genetic association or a cancer predisposition syndrome, the prognosis depends on accurate diagnosis. The application of molecular genetics to pediatric tumors has resulted in better diagnostic and prognostic factors for patient management. Molecular diagnostic techniques, such as reverse transcription polymerase chain reaction and fluorescence in situ hybridization (FISH), have become important tests for childhood tumors. Targeted therapies are aimed at specific translocations which are detected by FISH. Molecular techniques help in monitoring of minimal residual disease in childhood tumors.</p>

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“…Die WTS werden derzeit gemäß der aktuellen WHO-Klassifikation in mehr als 140 Entitäten und Subtypen unterteilt [1]. Das häufigste bei Kindern auftretende WTS ist das Rhabdomyosarkom (RMS) [1,2]. Die enorme histologische und biologische Heterogenität der WTS einerseits, und ihre Rarität anderseits, determinieren die Schwierigkeiten therapeutische Fragen zu klären.…”

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Therapie der Weichteilsarkome: mehr Fragen offen als beantwortet?

Kościelniak¹

2005

Wien Klin Wochenschr

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Soft-Tissue sarcoma in childhood and adolescence

Cited by 11 publications

References 26 publications

Molecular Genetics of Pediatric Soft Tissue Tumors

Molecular Genetics of Pediatric Soft Tissue Tumors

Molecular diagnosis of pediatric tumors

Therapie der Weichteilsarkome: mehr Fragen offen als beantwortet?

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