Soft tissue sarcoma in neurofibromatosis type 1: A rare case of malignant peripheral nerve sheath tumor of the skin

Chung, Young Hun; Jang, Jin Woo; Cho, Jae-Young

doi:10.5999/aps.01529

Cited by 1 publication

(1 citation statement)

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“…For STS, 13,400 new cancer cases, and 5,140 new deaths in 2023 were estimated for the United States of America (39). STS can be attributed to environmental and/or genetic risk factors (148)(149)(150). Germline mutations in the tumor suppressor gene TP53 are accountable for LFS and can contribute to the early onset of sarcomas and other tumors by causing genomic instability (149)(150)(151)(152).…”

Section: From Bench To Besideimmunotherapy As Standard Therapy For Ma...mentioning

confidence: 99%

From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases

Knoedler,

Huelsboemer,

Hollmann

et al. 2024

Front. Immunol.

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Malignancies represent a persisting worldwide health burden. Tumor treatment is commonly based on surgical and/or non-surgical therapies. In the recent decade, novel non-surgical treatment strategies involving monoclonal antibodies (mAB) and immune checkpoint inhibitors (ICI) have been successfully incorporated into standard treatment algorithms. Such emerging therapy concepts have demonstrated improved complete remission rates and prolonged progression-free survival compared to conventional chemotherapies. However, the in-toto surgical tumor resection followed by reconstructive surgery oftentimes remains the only curative therapy. Breast cancer (BC), skin cancer (SC), head and neck cancer (HNC), and sarcoma amongst other cancer entities commonly require reconstructive surgery to restore form, aesthetics, and functionality. Understanding the basic principles, strengths, and limitations of mAB and ICI as (neo-) adjuvant therapies and treatment alternatives for resectable or unresectable tumors is paramount for optimized surgical therapy planning. Yet, there is a scarcity of studies that condense the current body of literature on mAB and ICI for BC, SC, HNC, and sarcoma. This knowledge gap may result in suboptimal treatment planning, ultimately impairing patient outcomes. Herein, we aim to summarize the current translational endeavors focusing on mAB and ICI. This line of research may serve as an evidence-based fundament to guide targeted therapy and optimize interdisciplinary anti-cancer strategies.

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Section: From Bench To Besideimmunotherapy As Standard Therapy For Ma...mentioning

confidence: 99%

From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases

Knoedler,

Huelsboemer,

Hollmann

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Soft tissue sarcoma in neurofibromatosis type 1: A rare case of malignant peripheral nerve sheath tumor of the skin

Cited by 1 publication

References 0 publications

From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases

From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases

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