Soft tissue sarcoma of the head and neck in children and adolescents

Lyos, Andrew T.; Goepfert, Helmuth; Luna, Mario A.; Jaffe, Norman; Malpica, Anaís

doi:10.1002/(sici)1097-0142(19960101)77:1<193::aid-cncr31>3.0.co;2-z

Cited by 58 publications

(28 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the Agency for Research on Cancer, soft-tissue sarcomas account for 4%-8% of cancers in patients up to 14 years of age (2,(35)(36)(37). Whereas head and neck primary sarcomas represent only 5%-15% of all adult sarcomas, 35% of all sarcomas in the pediatric population manifest in the head and neck (38 -40).…”

Section: Acquired Lesions Sarcomas Of the Head And Neckmentioning

confidence: 99%

Lumps and Bumps on the Head in Children: Use of CT and MR Imaging in Solving the Clinical Diagnostic Dilemma

et al. 2004

View full text Add to dashboard Cite

Section: Acquired Lesions Sarcomas Of the Head And Neckmentioning

confidence: 99%

Lumps and Bumps on the Head in Children: Use of CT and MR Imaging in Solving the Clinical Diagnostic Dilemma

et al. 2004

View full text Add to dashboard Cite

“…4 These tumors are more common in childhood, and up to 33% occur in the head and neck region. 5,6 The skull base is one of the common anatomic regions involved in head and neck sarcomas. 7,8 The majority of these patients present with symptoms, the most frequent of which is a painless mass.…”

mentioning

confidence: 99%

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Gil

Patel

Singh

et al. 2007

Cancer

View full text Add to dashboard Cite

BACKGROUND. Single‐institutional studies lack sufficient power to assess the role of surgery and radiotherapy in the management of sarcomas involving the anterior skull base. For this study, an international collaborative study group analyzed a large cohort of patients who underwent surgery for the treatment of skull base tumors. METHODS. A subset of 146 patients who had a histologic diagnosis of skull base sarcoma (SBS) formed the basis of this report. Most patients were aged ≥21 years (77%) and had stage IV disease (56%). Adjuvant radiotherapy was received by 35% of patients, and chemotherapy was received by 10% of patients. RESULTS. Orbital involvement was encountered in 53% of patients, involvement of the orbital wall was encountered in 46% of patients, and intracranial extension was encountered in 28% of patients. Positive microscopic margins were reported in 43% of patients (51 of 118 patients). Treatment‐related complications were reported in 27% of patients, and postoperative mortality was reported in 1.4% of patients. With a median follow‐up of 34 months, the 5‐year overall, disease‐specific, and recurrence‐free survival rates were 62%, 64%, and 57%, respectively. Tumor grade and adjuvant radiotherapy were not significant predictors of survival. Prior radiotherapy, intraorbital extension, positive margins, and postoperative complications were significant predictors of reduced disease‐specific survival on univariate analysis. The presence of positive/close margins, however, was the only independent predictor of poor overall, recurrence‐free, and disease‐specific survival on multivariate analysis (relative risk, 2.4; P = .006). The 5‐year disease‐specific survival rate was 77%, 43%, and 36% for patients with negative, close, and positive margins, respectively. CONCLUSIONS. The current results indicated that wide craniofacial resection with negative margins is an independent prognostic predictor of better outcome. Patients with positive margins have a high risk for tumor recurrence independent of tumor grade. Cancer 2007. © 2007 American Cancer Society.

show abstract

“…There is a slight male predisposition for sarcomas tumor. 13,14 The mean age in out sample was 7.79 years; males predominated slightly (54.17%) compared to females (45.83%). Lyos et al found similar results in a study of 134 patients where the mean age was 7 years and the male to female ratio was 1.2:1.…”

Section: Discussionmentioning

confidence: 94%

Rabdomiossarcoma de cabeça e pescoço: 24 casos e revisão da literatura

Moretti¹,

Guimarães²,

Oliveira³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

View full text Add to dashboard Cite

Rhabdomyosarcoma (RMS) is a malignant tumor of soft tissues, more common in childhood, mainly located in the head and neck. It presents varied clinical and biological behavior and requires individualized management. Aim To describe information on patients with head and neck RMS diagnosed and treated in a hospital, and to compare them to results in the literature. Study design: Descriptive and retrospective. Materials and Methods A retrospective analysis of data from 24 patients with head and neck rhabdomyosarcoma diagnosed and treated in a hospital from 1994 to 2008. Results The mean age was 7.79 years. According to gender, 54.17 % were males and 45.83 % were female. All patients underwent chemotherapy (CT), 62.5% of them also underwent radiotherapy (RT) and 16.67% were submitted to surgery. Of the 24 patients, 8 (33.3%) died, 6 (25%) were found free of neoplasia and 2 (8.3%) experienced tumor recurrence. Conclusion The RMS of the head and neck often presents with nonspecific symptoms. Individualized multimodal therapy should be performed for these patients, including surgery, chemotherapy and radiotherapy.

show abstract

Soft tissue sarcoma of the head and neck in children and adolescents

Abstract: Prognostic indicators for NRSTS include completeness of tumor resection and the development of recurrent disease.

Cited by 58 publications

References 40 publications

Lumps and Bumps on the Head in Children: Use of CT and MR Imaging in Solving the Clinical Diagnostic Dilemma

Lumps and Bumps on the Head in Children: Use of CT and MR Imaging in Solving the Clinical Diagnostic Dilemma

Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study

Rabdomiossarcoma de cabeça e pescoço: 24 casos e revisão da literatura

Contact Info

Product

Resources

About