Soft Tissue Sarcomas

Hickeson, Marc

doi:10.1007/0-387-34641-4_16

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…Early detection of postoperative soft tissue sarcoma residual/recurrence allows a larger variegation of treatment choices and results in better prognosis than late identification of recurrence. [ 5 ] Therefore, early detection of recurrence is crucial to treat sarcomas, making it the main goal of postoperative MRI.…”

Section: Discussionmentioning

confidence: 99%

Can MRI diffusion-weighted imaging identify postoperative residual/recurrent soft-tissue sarcomas?

ElDaly

Moustafa

Abdel-Meguid

et al. 2018

Indian Journal of Radiology and Imaging

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Purpose:The aim of this study was to evaluate contrast-enhanced magnetic resonance imaging (CE-MRI) and quantitative diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping in the detection of recurrent/residual postoperative soft tissue sarcomas.Materials and Methods:This study included 36 patients; 27 patients had postoperative recurrent/residual soft tissue sarcomas and 9 patients had postoperative and treatment-related changes (inflammation/fibrosis). The DWI was obtained with 3 b values including 0, 400, and 800 s/mm2. Calculation of the ADC value of the lesion was done via placing the region of interest (ROI) to include the largest area of the lesion. ADC values were compared to histopathology.Results:Our results showed that including CE-MRI improved the diagnostic accuracy and sensitivity in recurrence detection compared to conventional non-enhanced sequences. However, it showed low specificity (55.56%) with a high false-positive rate that may lead to an unnecessary biopsy of a mass such as region of postoperative scar tissue.Conclusion:The joint use of gadolinium-enhanced MRI and quantitative DWI with ADC mapping offer added value in the detection of recurrent/residual postoperative soft tissue sarcoma. This combined use increased both the diagnostic sensitivity and specificity with a cut-off average ADC value for detecting nonmyxoid recurrent/residual lesions ≤1.3 × 10−3 mm2/s (100% specificity and 90.48% sensitivity). Our results showed limited value of DWI with ADC mapping in assessing myxoid sarcomatous tumor recurrences.

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Section: Discussionmentioning

confidence: 99%