Soft tissue sarcomas of the head and neck: a single‐centre experience

Lajer, Christel; Daugaard, Søren; Hansen, Hanne Sand; Kirkegaard, Jørgen; Holmgaard, S.; Christensen, Merrill J.

doi:10.1111/j.1365-2273.2004.00951.x

Cited by 15 publications

(20 citation statements)

References 27 publications

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“…In our study, most of the patients were treated with surgery + radiotherapy + chemotherapy, representing 27.8% of the cases, and surgery + radiotherapy, also with 27.8% of the cases. Other authors found lower frequencies; Penel et al 9 found 14.2% and 21.4% respectively, and Lajer et al 8 , 16.6% and 13.8%, respectively. Most studies show a large frequency of patients who were submitted to surgery only, as the studies by Bentz et al 19 , with 77% of patients, and that of Lajer et al 8 , with 52.7%.…”

Section: Discussionmentioning

confidence: 93%

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Clinicopathological study of patients with head and neck sarcomas

Pacheco¹,

Alves²,

Mota³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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Sarcomas are rare tumors, mainly stemming from the embryonic mesoderm, with a high grade of morbidity and mortality.Objective: To carry out a retrospective study of head and neck sarcoma cases between 1999 and 2008 in three specialized centers in the city of Fortaleza. Materials and Methods:Data collection was based on the charts of the patients in the study. For statistical analysis purposes we used the chi-square associations and the z test for proportions.Results: We found records of 36 patients, and the most affected ones were adult brown males, in the age range between 20 and 59 years -mean age of 39.7. The man/woman ratio was 1.76:1. The most prevalent histological type was the rhabdomyosarcoma and their most common locations were the face and the neck. Most of the sample was made up of live patients without evidence of the disease in the last visit -41.6% of the cases. The most common treatment modes were the combination of surgery + radiotherapy + chemotherapy and surgery + radiotherapy, with 27.8% of the cases each. Conclusion:Sarcomas have a great histological variability and may have numerous locations. Since these are rare and not well-known lesions, new epidemiological studies must be carried out in order to enhance our understanding of the disease. Braz J Otorhinolaryngol. 2011;77(3):385-90. ORIGINAL ARTICLE

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Section: Discussionmentioning

confidence: 93%

“…Gorsky and Epstein, 3 in a study on sarcomas and soft tissues, noticed that oral sarcomas represented 0.14% of all head and neck cancers, which shows how rare these tumors are. Lajer et al 8 reported from their study that oral sarcomas represented 27.7% of these head and neck tumors, and Penel et al 9 reported a 10.7% frequency.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological study of patients with head and neck sarcomas

Pacheco¹,

Alves²,

Mota³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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“…1,4,5 However, recent reviews of pathologic soft tissue sarcoma material have changed the proportions of different sarcoma types in favor of LMS. 2,[6][7][8] Methodological advances in immunohistochemistry and molecular genetics have improved diagnostic accuracy vastly, and the majority of intraabdominal LMS have been reclassified as gastrointestinal stromal tumors.…”

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confidence: 99%

Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the Scandinavian Sarcoma Group

Svarvar¹,

Böhling²,

Berlin³

et al. 2007

Cancer

127

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BACKGROUND.Leiomyosarcoma of nonvisceral soft tissues is an uncommon malignant tumor; thus, only small numbers of cases have been reported. This study was based on a large series of patients from the Scandinavian Sarcoma Group Register acquired during a 15‐year period (from 1986 to 2001). Follow‐up information was available for all patients.METHODS.The authors analyzed the clinical features of 225 patients with cutaneous, subcutaneous, or deep‐seated leiomyosarcoma of the extremities, trunk wall, and superficial parts of the head and neck region to determine the natural course of the disease. Only patients who received their treatment at a specialist sarcoma center were included. Re‐evaluation of histopathology was performed.RESULTS.The age of the patients (121 women and 104 men) ranged from 20 years to 98 years (median, 70 years), and the tumors ranged in size from 0.6 cm to 35 cm (median, 4.0 cm). Eighty‐two percent of the tumors were classified as high grade. The median follow‐up for survivors was 5.5 years. The local treatment was adequate in 154 of 206 patients (75%) who were without metastasis at presentation. At 10 years, 84% of the 206 patients with localized disease at presentation were free from local recurrence, 66% remained metastasis free, and 49% were alive. Multivariate analysis showed that higher malignancy grade (P = .006), larger tumor size (P = .003), and deeper tumor location (P = .002) were correlated significantly with decreased metastasis‐free survival, inadequate local treatment was correlated with local recurrence (P = .007), and high malignancy grade was correlated with decreased overall survival (P = .007).CONCLUSIONS.The long‐term prognosis for patients with subcutaneous and deep‐seated soft tissue leiomyosarcoma remains poor despite the ability to achieve adequate local control through nonmutilating surgery with or without radiotherapy. Cancer 2007. © 2006 American Cancer Society.

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“…13 Two further cases of pharyngeal leiomyosarcoma have been described, but their exact site was unknown. 14, 15 The differential diagnosis of leiomyosarcoma includes leiomyoma, malignant melanoma, spindle cell SCC and sarcoma. Diagnosing leiomyosarcoma based on microscopy alone can be difficult, and immunohistochemical and ultrastructural investigation may be required.…”

Section: Discussionmentioning

confidence: 99%