A 56-year-old woman was admitted for a 5-year history of a painless right arm mass. The patient denied any recent enlargement. However, over the previous 2 years, the patient complained of gradually increasing numbness at the thumb, index finger, and middle finger of the ipsilateral arm. There was no history of trauma. Medical and family history was unremarkable.Physical examination revealed a soft, oval, deep palpable mass on the medial side of her right arm with a maximum diameter of 4 cm (Fig. 1). Passive and active range of motion of the right elbow and hand were unaffected. Neurologic examination was normal. Routine laboratory analysis including complete blood cell count, serum chemistries, erythrocyte sedimentation rate, and C-reactive protein were within normal limits.We performed plain radiography ( Fig. 2), ultrasonography (Fig. 3), and MRI (Fig. 4).Based on the history, physical examination, laboratory tests, and imaging studies, what is the differential diagnosis?
Imaging InterpretationA frontal radiograph of the right upper arm showed a cluster of rounded calcifications in the soft tissues along the medial aspect of the mid humerus. No underlying osseous abnormality was noted (Fig. 2).Ultrasonography of the right arm showed a well-defined oval mass with heterogeneous internal echogenicity. The mass was closely related to the median nerve. Doppler examination revealed a moderate degree of vascularity within the lesion (Fig. 3).MRI showed a fusiform lesion with well-circumscribed borders along the posteromedial aspect of the biceps. The lesion was intermuscular and centered along the expected course of the median nerve. The normal median nerve could not be identified as a distinct structure at this level. The lesion was heterogeneous and slightly hypointense to muscle on T1-weighted images (Fig. 4A-B) and heterogeneously hyperintense on T2-weighted images. On postcontrast T1-weighted images (Fig. 4C-D), the mass enhanced in fairly uniform fashion.
Differential Diagnosis
Hemangioma SchwannomaEach author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article. Each author certifies that his or her institution has approved the reporting of this case and that all investigations were conducted in conformity with ethical principles of research.