Soft‐Tissue Tumours and Tumour‐Like Conditions

Calonje, Eduardo

doi:10.1002/9780470750520.ch53

Cited by 45 publications

(94 citation statements)

References 716 publications

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“…13 Piloleiomyoma can occur at any age from birth onwards, but usually appears in early adult life. 13 Piloleiomyoma can occur at any age from birth onwards, but usually appears in early adult life.…”

Section: Discussionmentioning

confidence: 99%

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Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas

Kagimoto

Yamasaki

Shimada-Ohmori

et al. 2016

The Journal of Dermatology

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Cutaneous leiomyomas are benign smooth muscle tumors that are occasionally painful. The mechanism of pain related to leiomyoma is not fully understood. To investigate the possible involvement of algoneic factors in pain from cutaneous leiomyomas. We present a case of cutaneous leiomyoma with severe, diffused pain in a large area and collected 10 more specimens of cutaneous leiomyoma with or without pain in patient histories. We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE2, BDKRB2, VR1 and CGRP. We compared the pain area and expression of algoneic factors to reveal possible correlations. We describe here a patient with a cutaneous leiomyoma 1-cm in diameter, which caused severe pain diffused throughout an area of 20-cm around the tumor. The pain completely resolved after surgical excision of the leiomyoma. We observed that the leiomyoma cells expressed CGRP, PGE2 and VR1 in this case. We found a positive correlation between VR1 and PGE2 expression in the leiomyoma cells and areas with pain around the tumors among 11 specimens in total. VR1 and PGE2 might be key algogenic substances in painful leiomyoma.

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Section: Discussionmentioning

confidence: 99%

“…13 In genital leiomyomas, pain is less frequent than in cases of piloleiomyoma. Piloleiomyomas are often subject to episodes of pain, and nearly 90% of patients report lesion-associated pain.…”

Section: Discussionmentioning

confidence: 99%

Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas

Kagimoto

Yamasaki

Shimada-Ohmori

et al. 2016

The Journal of Dermatology

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“…It is usually seen on the fingers but can also affect other parts of the hand, hence it has been proposed that the word ‘digital’ be removed from the nomenclature and it be called acquired acral fibrokeratoma. The lesion can be either a skin‐coloured, slightly keratotic, exophytic, finger‐like projection protruding from the skin or a papulonodule 1,2 . A colarette of raised skin at the base has also been described 1 .…”

Section: Discussionmentioning

confidence: 99%

“…The lesion can be either a skin‐coloured, slightly keratotic, exophytic, finger‐like projection protruding from the skin or a papulonodule 1,2 . A colarette of raised skin at the base has also been described 1 . The surface of the lesion may be smooth or slightly warty.…”

Section: Discussionmentioning

confidence: 99%

Finger-like projection on a finger

Verma¹

2008

Clinical and Experimental Dermatology

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“…Angiosarcoma (AS) of the scalp is a rare disease for which there has been no effective chemotherapy. Therefore, a combination of resection with a wide and deep margin and radiation has been recommended 1. However, the outcomes of such combination therapy have been poor 2.…”

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confidence: 99%

Docetaxel: A therapeutic option in the treatment of cutaneous angiosarcoma

Nagano

Yamada

Ikeda

et al. 2007

Cancer

127

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BACKGROUND.Effective treatment options are limited for patients with cutaneous angiosarcoma (AS). Docetaxel, a member of the taxane family of drugs, reportedly has been effective in the treatment of lung, head and neck, and breast cancers. Another taxane drug, paclitaxel, reportedly had unique activity in the treatment of AS of the scalp and neck and acquired immunodeficiency syndrome‐related Kaposi sarcoma. Therefore, the authors hypothesized that docetaxel may be of value in the treatment of cutaneous AS that is resistant to conventional therapy. However, there were only 3 case reports of the successful treatment of AS in elderly patients using docetaxel in combination with surgery and radiotherapy.METHODS.This was a retrospective trial. After written informed consent was obtained, docetaxel was administered intravenously at a dose of 25 mg/m2 for 1 hour weekly over a period of 8 weeks on the basis of previous reports. This treatment regimen was received by 9 patients with cutaneous AS who were treated at Kobe University Hospital between January 2003 and October 2006.RESULTS.Six of the 9 patients who received treatment achieved major responses, including 2 complete responses and 4 partial responses. Neutropenia and peripheral neuropathy were not prominent, although severe radiation dermatitis enhanced by the docetaxel was observed in 3 patients. There were no deaths attributable to this therapy.CONCLUSIONS.The current study demonstrated that docetaxel was effective in patients with cutaneous AS. Cancer 2007. © 2007 American Cancer Society.

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Soft‐Tissue Tumours and Tumour‐Like Conditions

Cited by 45 publications

References 716 publications

Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas

Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas

Finger-like projection on a finger

Docetaxel: A therapeutic option in the treatment of cutaneous angiosarcoma

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