Soft-Tissue Uptake of 99mTc-Diphosphonate and 99mTc-Pyrophosphate in Systemic AA and AL Amyloidosis

Janssen, Sven; Piers, Da; Rijswijk, M.H. van; Mandema, E

doi:10.1007/978-1-4613-2199-6_79

Cited by 7 publications

(7 citation statements)

References 11 publications

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“…Nuclear imaging of amyloid deposits has been attempted with various tracers like 99mTc-pyrophosphate or diphosphonates [25,[28][29][30], gallium-67 citrate [31] and 99mTc(V)dimercaptosuccinic acid (DMSA) [32,33]. All these radiopharmaceuticals share the common feature of being non-specific for amyloidosis and accumulating in quite a large variety of pathological tissues.…”

Section: Discussionmentioning

confidence: 99%

Cardiac and pleuropulmonary AL amyloid imaging with technetium-99m labelled aprotinin

et al. 1995

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Antiproteases are known to be present in amyloid deposits. We evaluated the possibility of using an anti-serine protease (aprotinin) labelled with technetium-99m (TcA), usually employed as a cortical renal tracer, for the imaging of amyloid deposits. Because of the known high uptake of TcA by the kidneys, we limited our analysis to extra-abdominal amyloid localizations. We report the scintigraphic findings observed in 24 patients with light chain amyloidosis (AL) and one with a hereditary form who were known or suspected to have extra-abdominal involvement. Planar scans obtained 100min after i.v. TcA administration showed myocardial accumulation in 11 patients, pleuropulmonary accumulation in nine, pericardial accumulation in two and localization in the neck region (thyroid, salivary glands and tongue) in eight. TcA scintigraphy was negative in five patients without clinical or laboratory evidence of extra-abdominal involvement, as well as in 12 control group patients with cardiac and renal diseases. These preliminary results indicate TcA to be a low-cost, readily available radiopharmaceutical for imaging of extra-abdominal involvement in AL type amyloidosis.

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Section: Discussionmentioning

confidence: 99%

Cardiac and pleuropulmonary AL amyloid imaging with technetium-99m labelled aprotinin

et al. 1995

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“…Echocardiography, however, was more sensitive for demonstrating cardiac involvement than both phosphate-derivatives. In general, 99m Tc-MDP images showed a better contrast than 99m Tc-PYP images [56].…”

Section: Amyloid Deposits 99m Tc-aprotininmentioning

confidence: 80%

Nuclear imaging in cardiac amyloidosis

Glaudemans

Slart

Zeebregts

et al. 2009

Eur J Nucl Med Mol Imaging

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Amyloidosis is a disease characterized by depositions of amyloid in organs and tissues. It can be localized (in just one organ) or systemic. Cardiac amyloidosis is a debilitating disease and can lead to arrhythmias, deterioration of heart function and even sudden death. We reviewed PubMed/Medline, without time constraints, on the different nuclear imaging modalities that are used to visualize myocardial amyloid involvement. Several SPECT tracers have been used for this purpose. The results with these tracers in the evaluation of myocardial amyloidosis and their mechanisms of action are described. Most clinical evidence was found for the use of 123 I-MIBG. Myocardial defects in MIBG activity seem to correlate well with impaired cardiac sympathetic nerve endings due to amyloid deposits. 123 I-MIBG is an attractive option for objective evaluation of cardiac sympathetic level and may play an important role in the indirect measurement of the effect of amyloid myocardial infiltration. Other, less sensitive, options are 99m Tc-aprotinin for imaging amyloid deposits and perhaps 99m Tc-labelled phosphate derivatives, especially in the differential diagnosis of the aetiology of cardiac amyloidosis. PET tracers, despite the advantage of absolute quantification and higher resolution, are not yet well evaluated for the study of cardiac amyloidosis. Because of these advantages, there is still the need for further research in this field.

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“…2). 51,52 A similar tracer (3,3-diphosphono-1,2-propanodicarboxylic acid) has also been shown to be useful for this purpose. 53,54 SAP scintigraphy was developed in London by Hawkins and colleagues 55 to detect and identify the distribution of amyloid in systemic amyloidosis.…”

Section: Imaging Of Amyloidosismentioning

confidence: 99%