Soft-Tissue Uptake of Tc-99m DPD (Dicarboxypropane Diphosphonate) in Amyloidosis

Noninvasive Etiologic Diagnosis of Cardiac Amyloidosis Using 99m Tc-3,3-Diphosphono-1,2-Propanodicarboxylic Acid Scintigraphy

“…The data are broadly in line with the single published study of 99m Tc-DPD scintigraphy in a small series of patients in familial TTR-related cardiac amyloidosis (17). In the only patient with AL amyloidosis reported in the literature to have myocardial uptake of 99m Tc-DPD, the etiologic diagnosis was based only on the presence of abnormal protein at serum and urine electrophoresis (a potentially misleading finding) (16).…”

“…Relatively few studies are available on the diagnostic performance of 99m Tc-DPD (16,17), 99m Tc-methylene diphosphonate, or 99m Tc-hydroxymethylene-diphosphonate in amyloidosis (18 -20). The numbers of patients included in these studies were often low, and the type of amyloidosis was frequently unspecified.…”

Role of 99m Tc-DPD scintigraphy on discrimination of familial cardiac amyloidosis

“…However, 99m Tc-DPD cannot replace echocardiography because of its low sensitivity, being complementary as demonstrated by the finding of abnormal uptake in a patient with normal echocardiographic exam. The first description involving the use of DPD in amyloidosis was performed by De Haro et al, where a patient with amyloidosis AL type (for immunoglobulin light chains) showed uptake in heart projection, parotid gland, uterus and gastrointestinal tract [6]. In 2002, Puille et al [7] have shown for the first time in 8 patients with ATTR, abnormal uptake of DPD in the heart.…”