Hybrid digital–analog transmission of video signals enables flexibility in dividing video information into two parts to utilize the available bandwidth better. This study proposes a compression scheme to reduce the utilized bandwidth. The scheme uses different subsampling in three-dimensional (3D) blocks, where subsampling factors are selected to minimize reconstruction distortion. The study evaluates various methods for subsampling and reconstruction to find the best combination in terms of reconstruction quality and complexity. Results show that medium-quality reconstructions can be obtained for compression ratios of about 0.125–0.3 samples per pixel.