Background Tobacco control strategies have led to an overall decline in smoking; however, a large gap remains between people with and without mental health problems, leading to substantial health inequalities. We aimed to assess mental health status of cigarette smokers and recent ex-smokers in England, and smoking and harm reduction behaviour and quit attempts by mental health status.Methods Data were collected from 5,637 current and 434 recent ex-smokers in 2016/17 in household surveys of representative samples of adults. We calculated weighted prevalence of different indicators of mental health problem: a) ever diagnosis, b) none, moderate or serious past-month distress, c) past-year treatment. We compared weighted smoking status, cigarette type, dependence, motivation to stop smoking, cutting down, use of nicotine replacement therapy or e-cigarettes, short-term abstinence, and quit attempts according to mental health status.Results Among smokers and recent ex-smokers, 35.9% ever had a diagnosis, 24.3% had experienced moderate, an additional 9.7% serious, past-month distress; 21.9% had had past-year treatment. Those with an indication of a mental health problem were more highly dependent and more likely to smoke roll-your-own cigarettes but also more likely to be motivated to stop smoking, to cut down, use nicotine replacement therapy or e-cigarettes and to have attempted to quit in the past year.Conclusions About a third of cigarette smokers in England have mental health problems. They are more dependent on cigarettes but also more likely to engage in harm reduction behaviours, more motivated to stop and more likely to attempt to stop smoking.