A misconception is a concept differing from experts' explanation, resulting in confusion among students. This study aims to apply the conceptual change learning model with a combination of predict-observe-explain to overcome students' misconceptions about the concept of chemical bonds. The research method was quasi-experimental. The samples were186 students at MAN (Islamic State Senior High School) Banda Aceh. Students' chemical bonding misconceptions were identified by the four-tier test, and data were then analyzed by the Mann-Whitney test. The results showed a decrease in misconceptions by 0.64 (medium) and 0.05 (low) in the experimental and control classes. Data analysis results showed a significant difference in the decrease of misconceptions between the experimental and control class. This implies that the conceptual change learning model combined with predict-observer-explain can reduce student misconceptions on chemical bonding.