The purpose of this study was to reveal that reconstructed soil composed of different types and proportions of materials has different effects on the growth of Melilotus officinalis, and to determine the most suitable formula of reconstructed soil materials to use for soil replacement. Using topsoil, coal gangue, fly ash, and rock and soil stripping materials from Shengli Mining Area of Inner Mongolia as raw materials, stratified and mixed pot experiments were carried out in a greenhouse using different proportions of each material. The differences in the aboveground biomass, leaf width, plant height, and root length of Melilotus officinalis plants in pot experiments were then compared using analysis of variance. The results showed that using different combinations of materials in different proportions affected the growth status of Melilotus officinalis, and their effects on biomass were greater than their effects on plant height, root length, and leaf width. When topsoil, coal gangue, and rock and soil stripping materials were mixed at a ratio of 3:3:4, respectively, the biomass of Melilotus officinalis increased by nearly 30% compared with that of plants potted in pure topsoil. When the content of coal gangue was controlled to be 30%, the content of fly ash was below 10%, and the content of rock and soil stripping materials was below 40%, the reconstructed soil conditions clearly promoted the growth of Melilotus officinalis. Coal gangue, rock and soil stripping materials, and fly ash can thus be used as substitutes for topsoil. Mixing soil reconstruction materials in the optimal proportion can solve the scarcity of topsoil in the grassland mining areas in the study region and, at the same time, can effectively improve the utilization of solid waste in this mining area.