The authors consider finite element models of a large-span building with a cylinder-and-slab roof as a large spatial mechanical system with different boundary conditions. The first model represents the superstructure of the building with a fixed-end at the soil base level. In the second model, the superstructure is based on the substructure, which includes a pile foundation and a soil base with different physical and mechanical properties. The purpose of the study is a comparative numerical analysis of the stress-strain state of a large-span building with different boundary conditions. The numerical study revealed the influence of the structural features of the substructure of the building, as well as the physical and mechanical properties of the soil base on the stress-strain state of the long-span roof and the building as a whole. Numerical static analysis of spatial finite element models of a large-span building was carried out in the СAE class Femap NX Nastran software package. The results of the static analysis demonstrated a significant structural influence of the substructure of a large-span building on the characteristics of its stress-strain state. In the next article, it is proposed to conduct a modal analysis for these building models.