SOL-detectability of liver SPECT. Analysis of the structure of ROC-curve.

Matumoto, Toru; Iinuma, Takeshi; ISHIKAWA, Tatuo; Tateno, Yukio; Kosaka, Noboru; Okada, Yoshitaka; Makita, K; Nishikawa, J; Machida, Kikuo; Iio, Masahiro; Seto, Kazuhiko; UNO, Koichi; Uchiyama, Guio; Mori, Yutaka; Kawakami, Kenji; Takagi, Yaeko; Kubo, Atsushi; Akiyama, Yoshihisa; Yui, Nobuharu; Nakajima, Tetsuo; Murata, Hajime; Kusakabe, Kiyoko; Oyamada, Hiyoshimaru

doi:10.3769/radioisotopes.34.9_486

Cited by 2 publications

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“…It has been reported that the diagnostic ability to occupy lesions can be improved by using SPECT [14,15]. Furthermore, recent studies have reported that attenuation and scatter can be accurately corrected by using a correction algorithm for single-photon emission computed tomography in combination with computed tomography (SPECT/CT) [16][17][18].…”

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confidence: 99%

Effect of position and volume of spaceoccupying liver lesions on liver function index in 99mTc-GSA scintigraphy

et al. 2021

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The authors aimed to elucidate the effect of liver space-occupying lesions (SOL) on the quantitative index of the hepatic reserve, calculated using the dynamic planar image (LHLplanar), and a three-dimensional quantitative index (LHLSPECT) calculated using quantitative combined modality single-photon emission computed tomography (SPECT/CT). Water balloons of different volumes that simulated liver SOL were placed in various positions in the combined cardiac-liver phantom to examine the effects of liver SOL on visualization and quantitative indicators (LHLplanar and LHLSPECT). A 200 mL water balloon was placed in the anterior right, posterior right, left medial and left lateral lobes in the liver phantom to compare LHLplanar and LHLSPECT values with and without liver SOL at each position. Subsequently, volumes of those in the front of the right lobe were changed to 50 mL, 100 mL, 200 mL, and 400 mL, followed by statistically comparing LHLplanar and LHLSPECT values in the presence and absence of liver SOL. Despite the variation in the degree of defect accumulation with the location of the balloon when using frontal planar imaging, quantitative SPECT/CT imaging identified all defects. Multiple comparison analysis revealed that unlike LHLSPECT, the LHLplanar values changed according to liver SOL position and volume. Liver SOL position and volume may affect the hepatic reserve assessments performed using LHLplanar values. In contrast, LHLSPECT is calculated using quantitative SPECT/CT and considers the effects of scattering and attenuation corrections. Therefore, LHLSPECT is a more accurate quantitative indicator of hepatic reserve than LHLplanar and is expected to facilitate future clinical research. In this paper, we try to outline the possible role of FDG PET/CT in the management of patients with TC and positive BRAF mutations and the impact that it could have on their therapeutic algorithm, in terms of thyroidectomy and radioactive iodine (RAI) therapy.

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Section: Introductionmentioning

confidence: 99%

Effect of position and volume of spaceoccupying liver lesions on liver function index in 99mTc-GSA scintigraphy

et al. 2021

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Retrospective evaluation of single photon emission computed tomography of the liver

et al. 1987

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Retrospective analysis, including indications for examination, of 335 consecutive liver examinations of adults with single photon emission computed tomography performed at the Karolinska Hospital during the first eight months of 1981 has been carried out. 85.1% of the investigations were performed in tumour patients. This group underwent retrospective evaluation specifically regarding space occupying lesions of the liver with a minimum follow-up time of 3 years. An adequate follow-up of 87.4% was achieved. The study showed a sensitivity of 82.7% and a specificity of 93.9%. The positive and negative predictive values were 78.2% and 95.4%, respectively. 4.4% of the examinations were regarded as equivocal. Compared to previously reported values for planar liver scintigraphy derived from several different studies, the tomographic technique produced no increase of specificity or positive predictive value but a higher total accuracy, probably due to better clarification of the hepatic anatomy. The false positive, false negative and equivocal diagnoses were analysed and reported.

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SOL-detectability of liver SPECT. Analysis of the structure of ROC-curve.

Cited by 2 publications

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Effect of position and volume of spaceoccupying liver lesions on liver function index in 99mTc-GSA scintigraphy

Effect of position and volume of spaceoccupying liver lesions on liver function index in 99mTc-GSA scintigraphy

Retrospective evaluation of single photon emission computed tomography of the liver

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