Sol–gel-derived manganese-releasing bioactive glass as a therapeutic approach for bone tissue engineering

Barrioni, Breno Rocha; Oliveira, Ana Celeste; Leite, Maria de Fátima; Pereira, Marivalda M.

doi:10.1007/s10853-017-0944-6

Cited by 56 publications

(43 citation statements)

References 106 publications

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“…FTIR transmission spectra are shown in Figure along with corresponding peaks. The peak at 440 cm −1 represents Si‐O‐Si bending vibration, whereas the peak at 800 cm −1 indicates symmetric stretching of Si‐O bond . Characteristic peaks located at 1038 and 1235 cm −1 are attributed to asymmetric stretching of Si‐O bond .…”

Section: Resultsmentioning

confidence: 99%

The effect of tantalum incorporation on the physical and chemical properties of ternary silicon–calcium–phosphorous mesoporous bioactive glasses

et al. 2019

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Synthesis and characterization of the first mesoporous bioactive glasses (MBGs) containing tantalum are reported here, along with their potential application as hemostats. Silica MBGs were synthesized using with the molar composition of (80‐x)% Si, 15% Ca, 5% P, and x% Ta. It was found that incorporation of >1 mol % Ta into the MBGs changes their physical and chemical properties. Increasing Ta content from 0 to 10 mol % causes a decrease in the surface area and pore volume of ~20 and ~35%, respectively. This is due to the increase in nonbridging oxygens and mismatch of thermal expansion coefficient which created discontinuities in the ordered channel structure. However, the effect is not significant on the amount of ions (Si, Ca, P, and Ta) released, from the sample into deionized water, for short durations (<60 min). In a mouse tail‐cut model, a significant decrease in bleeding time (≥50% of average bleeding time) was found for Ta‐MBGs compared to having no treatment, Arista, and MBG without Ta. Further studies are proposed to determine the mechanism of Ta involvement with the hemostatic process. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2229–2237, 2019.

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Section: Resultsmentioning

confidence: 99%

The effect of tantalum incorporation on the physical and chemical properties of ternary silicon–calcium–phosphorous mesoporous bioactive glasses

et al. 2019

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“…We have also previously demonstrated that different Mn-containing BG microparticle compositions derived from the sol-gel process can be obtained, with HCA layer formation in simulated body fluid (SBF) within less than 1 day [32]. An ion release study showed that Mn ion level could be adjusted [32] to lower concentrations than 0.1 mM, reported to inhibit osteoblasts proliferation and spreading [24], and contributing to the promise of such a composition as a potential strategy to obtain superior materials for bone repair. Further evaluation remains necessary to confirm the Mn potential on the osteogenic differentiation and bone mineralisation.…”

Section: Introductionmentioning

confidence: 98%

“…Although limited work in sol-gel derived BGs containing Mn is reported, sol-gel derived mesoporous BG nanoparticles were previously obtained, which showed in vitro bioactivity and also antibacterial effect [31]. We have also previously demonstrated that different Mn-containing BG microparticle compositions derived from the sol-gel process can be obtained, with HCA layer formation in simulated body fluid (SBF) within less than 1 day [32]. An ion release study showed that Mn ion level could be adjusted [32] to lower concentrations than 0.1 mM, reported to inhibit osteoblasts proliferation and spreading [24], and contributing to the promise of such a composition as a potential strategy to obtain superior materials for bone repair.…”

Section: Introductionmentioning

confidence: 99%

Osteogenic potential of sol–gel bioactive glasses containing manganese

Barrioni

Norris

et al. 2019

J Mater Sci: Mater Med

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We report that the release of manganese ions from bioactive glass provoked human mesenchymal stem cell (hMSC) differentiation down a bone pathway, whereas hMSCs exposed to the Mn-free glass did not differentiate. Bioactive glasses (BGs) are widely used for bone regeneration, and allow the incorporation of different ions with therapeutic properties into the glass network. Amongst the different ions with therapeutic benefits, manganese (Mn) has been shown to influence bone metabolism and activate human osteoblasts integrins, improving cell adhesion, proliferation and spreading. Mn has also been incorporated into bioceramics as a therapeutic ion for improved osteogenesis. Here, up to 4.4 mol% MnO was substituted for CaO in the 58S composition (60 mol% SiO2, 36 mol% CaO, 4 mol% P2O5) and its effects on the glass properties and capability to influence the osteogenic differentiation were evaluated. Mncontaining BGs with amorphous structure, high specific surface area and nanoporosity were obtained. The presence of Mn 2+ species was confirmed by X-ray photoelectron spectroscopy (XPS). Mn-containing BGs presented no cytotoxic effect on human mesenchymal stem cells (hMSCs) and enabled sustained ion release in culture medium. hMSCs osteogenic differentiation stimulation and influence on the mineralisation process was also confirmed through the alkaline phosphatase (ALP) activity, and expression of osteogenic differentiation markers, such as collagen type I, osteopontin and osteocalcin, which presented higher expression in the presence of Mn-containing samples compared to control. Mn incorporation offers great promise for obtaining glasses with superior properties for bone tissue regeneration.

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“…Several papers deal with the investigation of novel compositions of silicate and phosphate bioactive glasses, in particular glasses with therapeutic ion delivery capability to enhance cellular response, an area highlighted in one of the most recent papers authored by Larry Hench in 2015 [6], which reflects the importance of this topic for applications of bioactive glasses in regenerative medicine and as antibacterial agent. For example, novel bioactive silicate glasses (both melt-derived and solgel produced) incorporating B [7,8], bivalent ions such as Mg, Zn, Sr and Cu [9], Li [10], Ce [11], Sr [12,13], Cu, Zn [14], Mn [15], are discussed. The release of ''classical'' ions in bioactive glasses, namely Si, Ca, P, is the subject of the studies of Houreh et al [16] and Obata et al [17] in the context of dental pulp stem cells and osteoblast cell responses, respectively.…”

Section: ó Springer Science+businessmentioning

confidence: 99%