Sol–gel synthesis and in vitro bioactivity of glass–ceramics in SiO2–CaO–Na2O–P2O5 system

Abstract

Bioactive glass-ceramic powder in SiO 2 -CaONa 2 O-P 2 O 5 system was successfully synthesised through a modified sol-gel route. The gel was prepared using tetraethyl orthosilicate, calcium nitrate, sodium nitrate and triethyl phosphate raw materials. The gel was calcined in the temperature range 700-1050°C to get the glass-ceramic powder. Dissolution of the glass-ceramic powder was studied by in vitro immersion in Tris buffer solution for various period of time. The biodegraded powder was analyzed using XRD. The sintered glass-ceramic was characterized for in vitro bioactivity in simulated body fluid, and the incubated pellet was then analyzed for phase identification by XRD, surface morphology using SEM and elemental analysis using energy-dispersive X-ray analysis. The biocompatibility of the glass-ceramics was evaluated through MTT assay using MG-63 cells. Graphical Abstract

Assessment of sol–gel derived iron oxide substituted 45S5 bioglass-ceramics for biomedical applications

“…The combeite phase has been well studied and is found to have good mechanical strength and biodegradability. 15,39,40 The magnetic properties are attributed to available magnetic phases (magnetite and hematite) in the sol-gel powders. Though the crystallization of bioactive glass tends to decrease the bioactivity, crystallization of the combeite phase compensates for it and balanced the decrement in bioactivity.…”

Effect of Sr on the Bioactivity of Sol-Gel Derived New Silicate Bioglass S55P4

“…2 (b)) shows that the band observed at around 562 and 602 cm -1 associate with the P-O bond of the apatite formation. The appearance of these doublet P-O bond the most characteristic region for crystalline calcium phosphates including carbonated hydroxyapatite (CHA) which was the most typical section for apatite and other phosphates [24]. However, these two split bands were not clearly appeared for Sr(8) on 14-day soaking, which was still in a single band of amorphous P-O bond (600-570 cm -1 ) [25].…”