Solanum incanum extract enhances wound healing and tissue regeneration in burn mice model

Qureshi, Zainab; Khan, Taous; Shah, Abdul Jabbar; Wahid, Fazli

doi:10.3329/bjp.v14i2.40098

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…Step 8: The study of mesenchymal progenitors content in the wound, their functional activity, and production of growth factors by stromal cells from the surface of the wound. Goldberg et al, 2006;Zyuz'kov et al, 2012 Reference (video) Öz et al, 2016;Qureshi et al, 2019 Liability Company Assortiment Firm, Sergiev Posad city, Russia), water ad libitum. To exclude seasonal fluctuations of studied parameters, all the experiments were performed in the autumn-winter period.…”

Section: Methodsmentioning

confidence: 99%

Wound healing properties of the protein kinase A inhibitor and the mechanisms of their development

Зюзьков

Мирошниченко

Polyakova

et al. 2021

Bangladesh J Pharmacol

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The regenerative activity of the protein kinase A inhibitor was investigated using externally on the model of the flap skin wound. The pronounced wound healing effects of the protein kinase A inhibitor had been revealed. They are based on the activation of mesenchymal progenitor cells. The development of this phenomenon was associated with the direct influence of the protein kinase A inhibitor on mesenchymal progenitor cells. The most significant stimulation of their growth potential occurred in the context of the impact of growth factors in particular fibroblast growth factor secreted by the stromal cells. Moreover, in situ, there was an increase not only in proliferating activity but also in the intensity of the specialization processes of progenitors. Without cytokines stimulation, the change in the pattern of cellular cAMP-mediated signal does not affect the maturation rate of precursors.

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Section: Methodsmentioning

confidence: 99%

Wound healing properties of the protein kinase A inhibitor and the mechanisms of their development

Зюзьков

Мирошниченко

Polyakova

et al. 2021

Bangladesh J Pharmacol

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“…Extensive research has demonstrated the broadspectrum antibacterial activity of Melia azedarach, as evidenced by its inhibitory effects against Proteus mirabilis, Enterobacter aerogenes, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Bacillus subtilis (Abbas et al, 2017;Zahoor et al, 2015). Solanum incanum extracts have also exhibited notable bactericidal and nematicidal properties (Anwar, 2018), complemented by their traditional use in wound healing, pain relief, and treatment of protozoan infections (Mwonjoria et al, 2014;Qureshi et al, 2019;Waweru et al, 2017). These observations underscore the potential therapeutic value of these plant extracts in addressing drug-resistant bacterial infections and inspire further investigation into their antimicrobial mechanisms and potential applications in modern medicine.…”

Section: Introductionmentioning

confidence: 94%

In-vitro Synergistic Antimicrobial Activity of Melia azedarach and Solanum incanum Ethanolic Leaf Extracts Against the Staphylococcus aureus

Obat,

Shiundu,

Gikaru

et al. 2023

AJPAM

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The increasing challenges of adverse drug reactions, costly medicines, and antimicrobial resistance necessitate the exploration of safe and effective antimicrobial agents. This study aimed to evaluate the antimicrobial activity of ethanol leaf extracts from Melia azedarach and Solanum incanum against Staphylococcus aureus, a clinically significant pathogen known for its resistance to conventional antibiotics. The research design employed was an experimental study with three concentrations of the plant extracts (1g/ml, 1.4g/ml, and 2g/ml) tested against Staphylococcus aureus, and the standard antimicrobial agent, ciprofloxacin, served as a positive control, while ethanol served as a solvent control. The samples were prepared, and the experiments were conducted in triplicate, following established protocols. The choice of Melia azedarach and Solanum incanum was scientifically justified based on their well-documented traditional medicinal uses and previous reports of antimicrobial activity. Ethical approval was obtained from the Kabarak University Research Ethics Committee (KUREC), and a research permit was obtained from the National Commission for Science, Technology, and Innovation (NACOSTI). The results demonstrated significant anti-staphylococcal activity for both extracts, with Melia azedarach exhibiting superior efficacy compared to Solanum incanum at all concentrations tested. Moreover, the combined extracts displayed enhanced antimicrobial effects against Staphylococcus aureus compared to the individual extracts. Phytochemical analysis revealed the presence of tannins, coumarins, flavonoids, and anthraquinones in both extracts, with higher levels of steroidal glycosides in Solanum incanum. We recommend further phytochemical and pharmacological investigations to identify the active antimicrobial constituents in these plants. These findings hold promise in the development of novel therapeutic agents to combat infectious diseases, offering Melia azedarach and Solanum incanum as potential sources for drug development.

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“…Other medicinal uses include relieving pain in patients with menstruation, liver disease, onchocerciasis, pleurisy, pneumonia, and rheumatism [ 14 ]. Other plant parts are also commonly used to treat a wide range of dermatological problems, including ringworm, burns, sores, rashes, wounds, warts, carbuncles, inflammations, and benign tumors [ 15 ]. In the Libo Kemkem district, in the Amhara region of Ethiopia, it is claimed that the root part chewed and then taken as a juice has been used to treat diabetes mellitus [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…There have been numerous experimental studies that proved various parts of the plant have a variety of activities, including in vitro antimicrobial activity of the leaf, fruit, and stem extract [ 16 ]; analgesic and spasmolytic activity of the leaf extract [ 17 ]; anti-inflammatory and antinociceptive effects of the root extract [ 14 ]; antihyperlipidemic effect of the fruit extract [ 18 ]; in vitro antiprotozoal activity of the leaf extract [ 19 ]; wound healing and anti-inflammatory activity of the leaf extract [ 15 ]; and antischistosomal activity of the root extract [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice

Andargie

Sisay

Molla

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Conventional antidiabetic drugs are linked with a number of contraindications and untoward effects. The root decoction of Solanum incanum L. has traditionally been used to treat diabetes. However, its safety and efficacy have not been scientifically authenticated yet. Hence, the study was conducted in mice to corroborate its antidiabetic potential and safety profile. Methods. Using normoglycemic, oral glucose-loaded, and streptozotocin-induced diabetic mice models, the hypoglycemic and antihyperglycemic activities of 80% methanolic root extract were investigated. On streptozotocin-induced diabetic mice, the effect of the test extract on diabetic lipid profile and body weight was also investigated. Further, the in vitro α-amylase inhibition activity was assessed. Results. The test extract was safe at a limit test dose of 2 g/kg. Dose-dependent α-amylase inhibition activity was seen with peak percentage inhibition of 75.95% at 700 μg/mL. In normoglycemic mice, the plant extract showed statistically significant hypoglycemic activity at 200 and 400 mg/kg ( P < 0.001 ) at 6 h and 4 and 6 h of treatment, respectively; in oral glucose-loaded mice, at both the test doses, the glucose level was also significantly dropped at 120 ( P < 0.01 ) and 60 and 120 min ( P < 0.001 ), respectively; whereas, in the third model, the test extract showed significant antihyperglycemic activity at 100 mg/kg ( P < 0.05 ) on the 14th day and at 200 ( P < 0.01 ) and 400 mg/kg ( P < 0.001 ) on the 7th and 14th day of treatment. Similarly, following repeated administration of the test extract at 200 and 400 mg/kg, the body weight was significantly improved on the 14th day ( P < 0.05 ) and on the 7th and 14th day ( P < 0.01 ), respectively, while diabetic dyslipidemia after 14 days ( P < 0.05 ). Conclusion. The study revealed that the test extract showed promising antihyperglycemic and antihyperlipidemic activity. Thus, the findings back up its use in Ethiopian remedies for diabetes.

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Solanum incanum extract enhances wound healing and tissue regeneration in burn mice model

Cited by 8 publications

References 10 publications

Wound healing properties of the protein kinase A inhibitor and the mechanisms of their development

Wound healing properties of the protein kinase A inhibitor and the mechanisms of their development

In-vitro Synergistic Antimicrobial Activity of Melia azedarach and Solanum incanum Ethanolic Leaf Extracts Against the Staphylococcus aureus

Evaluation of Antidiabetic and Antihyperlipidemic Activity of 80% Methanolic Extract of the Root of Solanum incanum Linnaeus (Solanaceae) in Mice

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