Solanum melongena: A potential source of antifungal agent

Das, Jayshree; Lahan, Jyoti Prasad; Srivastava, Ranjan

doi:10.1007/s12088-010-0004-2

Cited by 21 publications

(14 citation statements)

References 4 publications

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“…The differential activity might be due to either difference in plant constituents in each extract or tolerance of the pathogens to different plant constituents. Similar observations were reported earlier [15][16][17]. The MIC of the chloroform extracts was recorded as 5.0 mg ml -1 for all the test dermatophytes, however this extract showed some activity at 0.5 mg ml -1 causing 38.4, 37.3 and 44.7 % inhibition of T. mentagrophytes, T. rubrum and T. tonsurans respectively.…”

Section: Resultssupporting

confidence: 88%

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Isolation and Characterization of Antidermatophytic Bioactive Molecules from Piper longum L. Leaves

et al. 2012

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Piper longum L. (Piperaceae) commonly known as ''long pepper'' is a well known medicinal plant in ayurveda. Different parts of this plant, such as root, seed, fruit, whole plant etc. are used traditionally in various ailments. Here we have investigated the antidermatophytic activity of sequentially extracted petroleum ether, chloroform, methanol and water extracts from P. longum leaf against Trichophyton mentagrophytes, T. rubrum, T. tonsurans, Microsporum fulvum and M. gypseum. Better activity of chloroform and methanol extracts was observed. The chloroform extract was selected for further study and the MIC value was recorded as 5.0 mg ml -1 against the test organisms. In the chloroform extract, tannins and phenolic compounds were detected. Further activity-guided fractionation of chloroform extract by silica gel column chromatography yielded nine major fractions. Among these, fraction-1, 4, 5 and 7 showed higher antidermatophytic activity. Fraction-4 on further purification by repeated column chromatography yielded a potential antidermatophytic fraction showing MIC value of 0.625 mg ml -1 against T. mentagrophytes and T. rubrum as determined by broth microdilution method. The major compounds were identified as 1,2-benzenedicarboxylic acid, bis(2-ethylhexyl) ester (C 24 H 38 O 4 ] (41.45 %), 2,2-dimethoxybutane (C 6 H 14 O 2 ] (13.6 %) and b-myrcene (C 10 H 16 ) (6.75 %) based on GC-MS data.

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Section: Resultssupporting

confidence: 88%

“…Extraction Shade dried powdered leaves (100 g) were extracted sequentially with petroleum ether, chloroform, methanol and water ( Fig. 1) [15]. The extracts were filtered using Whatman filter paper (No-1).…”

Section: Plant Materialsmentioning

confidence: 99%

Isolation and Characterization of Antidermatophytic Bioactive Molecules from Piper longum L. Leaves

et al. 2012

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“…It can be inferred that antimicrobial compounds are present mostly in ethyl acetate and n-butanol fractions, which might be medium polar to polar in nature. Similar obser -vations were also reported earlier in other medicinal plants (Teke et al, 2011;Das et al, 2010;Mazumder et al, 2012). Earlier in a study, higher range of antidermatophytic activity of hexane fraction of O. gratissimum leaves was reported (Silva et al, 2005).…”

Section: Resultssupporting

confidence: 88%

Antimicrobial activity of methanol extract and fractions from <i>Sarcochlamys pulcherrima</i>

Mazumder

Das

Gogoi

et al. 2014

Bangladesh J Pharmacol

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Antimicrobial evaluation of methanol extract of Sarcochlamys pulcherrima leaf and its hexane, ethyl acetate, n-butanol and water fractions against 31 strains of microorganisms, using agar well, agar disc diffusion, and broth microdilution methods, revealed the activity of methanol extract against Trichophyton mentagrophytes, Candida albicans, Staphylococcus aureus and Escheracia coli (zone of inhibition: 21-40 mm, 200 mg/mL, and MIC: 6.25-50 mg/mL). All fractions also displayed antimicrobial activity (5-20 mg/mL), indeed ethyl acetate and n -butanol fractions showed better activity (MIC: 0.156 to 2.5 mg/mL). C. albicans was most sensitive to n-butanol fraction (15 mm, 2.5 mg/mL). Ethyl acetate and n-butanol fractions were more active against T. mentagrophytes (12 mm at 1.25 mg/mL) and S. aureus (ethyl acetate-16 mm, n-butanol-14 mm at 0.625 mg/mL). E. coli was inhibited by n-butanol fraction (13 mm at 2.5 mg/ mL). Further, n-butanol fraction (400 µg/disc) exhibited promising activity against 14 bacteria, 2 dermatophytes and 2 yeasts strains. Article Info

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“…Antimicrobial activity of methanol, dichloromethane and petrol ether extracts of the fruits (Das et al, 2008).…”

Section: Fruitsmentioning

confidence: 99%

Antibacterial activity of selected Cameroonian dietary spices ethno-medically used against strains of Mycobacterium tuberculosis

Tekwu

Aşkun

Kuete

et al. 2012

Journal of Ethnopharmacology

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Solanum melongena: A potential source of antifungal agent

Cited by 21 publications

References 4 publications

Isolation and Characterization of Antidermatophytic Bioactive Molecules from Piper longum L. Leaves

Isolation and Characterization of Antidermatophytic Bioactive Molecules from Piper longum L. Leaves

Antimicrobial activity of methanol extract and fractions from <i>Sarcochlamys pulcherrima</i>

Antibacterial activity of selected Cameroonian dietary spices ethno-medically used against strains of Mycobacterium tuberculosis

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