A flat-plate collector is one of the most common solar collector systems due to its comparatively lower cost and maintenance. However, the performance of this type of collector is low; thus, research studies in the past decades have focused on improving its efficiency through various plate configurations and efficient working fluids. This study recognizes the research gap regarding the influence of nanoparticle shapes and their effects on improving the heat transfer properties in flat-plate collectors. In this study, fly ash nanofluid at 0.5% (with a range of nanoparticle sizes) was used as a working fluid to investigate the performance of a flat-plate collector. This study analyzed the behavior of the collector system via a range of Reynolds numbers in its laminar regime, between 800 and 2000. The results measured in this study showed that the maximum energy efficiency measured was 73.8%, which was recorded for the fly ash nanofluid at a nanoparticle size of 11.5 nm. At a Reynolds number of 2000, the fly ash nanofluid with a nanoparticle size of 11.5 nm showed a top heat loss coefficient of 4.78 W/m2K, while the top heat loss coefficient of a nanoparticle size (NPS) of 114 nm was 5.17 W/m2K. This study provides a framework for the significance of the nanoparticle size in the synthesis of nanofluids in both mono and hybrid composites and application in solar collector systems.