Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B–dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract

Saliou, Claude; Rimbach, Gerald; Moini, Hadi; McLaughlin, Laura; Hosseini, Saeed; Lee, Jeongmin; Watson, Ronald R.; Packer, Lester

doi:10.1016/s0891-5849(00)00445-7

Cited by 136 publications

(101 citation statements)

References 34 publications

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“…A review of antioxidative enzymes 72 . It has been found to inhibit UV-induced NF-κB-dependent gene expression in a concentration dependent manner in HaCaT keratinocytes 71 . Topical application of a gel containing pycnogenol significantly prevented UV-induced erythema in rat 73 .…”

Section: French Maritime Pine Bark Extractmentioning

confidence: 99%

“…The extract is a mixture of phenols and polyphenols (procyanidin derivates, catechin, epicatechin, taxifolin) and phenolic acids (caffeic, ferulic, p-hydroxybenzoic, vanillic, gallic, protocatechuic) 71,72 . Pycnogenol® has been found to have excellent free radical scavenger properties by enhancing the production Natural phenolics in the prevention of UV-induced skin damage.…”

Section: French Maritime Pine Bark Extractmentioning

confidence: 99%

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Natural phenolics in the prevention of UV-induced skin damage. A review

Svobodová¹,

Psotová²,

Walterová³

2003

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

384

262

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Section: French Maritime Pine Bark Extractmentioning

confidence: 99%

Section: French Maritime Pine Bark Extractmentioning

confidence: 99%

Natural phenolics in the prevention of UV-induced skin damage. A review

Svobodová¹,

Psotová²,

Walterová³

2003

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

384

262

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“…In one study, Skh : hr hairless mice pretreated with pycnogenol concentrations of 0.05-0.2% demonstrated a dose-dependent reduction of the inflammatory sunburn reaction (oedema) following minimally inflammatory daily exposures to solar-simulated UV radiation [105]. In another study, oral supplementation with pycnogenol appeared to ease the effects of UV radiation on the skin, specifically reducing erythema, in 21 volunteers [106]. The UV radiation level necessary to reach one minimal erythema dose (MED) was significantly elevated during supplementation.…”

Section: Some Notable Anti-oxidantsmentioning

confidence: 99%

Skin ageing and its treatment

Baumann¹

2007

The Journal of Pathology

548

477

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The effects of chronic sun exposure on skin are readily apparent when skin not typically exposed to the sun and skin regularly exposed to the sun are compared. While the sun is not the only aetiological factor in the dynamic process of skin ageing, it is the primary exogenous cause among several internal and environmental elements. Thus, photo-ageing, the main focus of this article, is a subset of extrinsic skin ageing. The influence of the sun in extrinsic skin ageing, as well as its role in potentially altering the normal course of intrinsic (also known as natural or cellular) ageing, is discussed. Telomeres, the specialized structures found at the ends of chromosomes, are believed to be integral to cellular ageing as well as in the development of cancer. The ageing process, both intrinsic and extrinsic, is also believed to be influenced by the formation of free radicals, also known as reactive oxygen species. The loss of collagen is considered the characteristic histological finding in aged skin. Wrinkling and pigmentary changes are directly associated with photo-ageing and are considered its most salient cutaneous manifestations. Such photodamage represents the cutaneous signs of premature ageing. In addition, deleterious consequences of chronic sun exposure, specifically various forms of photo-induced skin cancer, are also linked to acute and chronic sun exposure. The only known strategies aimed at preventing photo-ageing include sun avoidance, using sunscreens to block or reduce skin exposure to UV radiation, using retinoids to inhibit collagenase synthesis and to promote collagen production, and using anti-oxidants, particularly in combination, to reduce and neutralize free radicals.

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“…* Anthocyanins and tannins, present in several fruits such as grapes, pears act by inhibiting UVB-dependent activation of NF-kB, MAP kinase and COX-2 pathways downstream of the signalling kinases MKK4, MEK1, and Raf-1 [15,16]. * Pycnogenol, an extract of French maritime pine (Pinuspinaster Ait), prevents UV induced erythema as well as long-term effects, such as immune-suppression and tumour formation [17,18]. It also possesses regenerative skin properties, and prevents UVBinduced photo-aging [19,20].…”

Section: Antioxidantsmentioning

confidence: 99%

Sunscreens and Antioxidants as Photo-protective Measures: An update

Hassan¹,

Dorjay²,

Sami³

et al. 2013

Our Dermatol Online

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There are many photo-protective measures adopted for protection from the solar radiation especially the UV radiation spectrum, sunscreens being the main agents. Besides the traditional approach of topical use of sunscreens, both chemical and physical, a new approach has emerged to use systemic agents in the form of vitamins and minerals. In this review, we are describing the major aspects related to sunscreens and anti-oxidants as photo-protective measures.

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Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B–dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract

Cited by 136 publications

References 34 publications

Natural phenolics in the prevention of UV-induced skin damage. A review

Natural phenolics in the prevention of UV-induced skin damage. A review

Skin ageing and its treatment

Sunscreens and Antioxidants as Photo-protective Measures: An update

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