2001
DOI: 10.1016/s1011-1344(01)00201-9
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Solar UV irradiation and dermal photoaging

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Cited by 428 publications
(313 citation statements)
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“…On the other hand, photo-aging of the skin in vivo is a complex biological process affecting the dermis Scharffetter-Kochanek et al 2000;Wlaschek et al 2001). Skin fibroblasts cultivated in collagen matrix before exposure to UVB, mimic these major changes of the dermis with a down-regulation of COL1A1 and COL3A1, CTGF and FMOD and up regulation of MMP3.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, photo-aging of the skin in vivo is a complex biological process affecting the dermis Scharffetter-Kochanek et al 2000;Wlaschek et al 2001). Skin fibroblasts cultivated in collagen matrix before exposure to UVB, mimic these major changes of the dermis with a down-regulation of COL1A1 and COL3A1, CTGF and FMOD and up regulation of MMP3.…”
Section: Discussionmentioning
confidence: 99%
“…Reactive oxygen species (ROS) (Chakravarti and Chakravarti 2007), which are generated either as products of normal metabolism (Haenold et al 2005) or by interaction with environmental factors such as UV radiation (Yaar and Gilchrest 2007), are the primary agents of protein oxidation. The influence of ROS on cellular metabolism has been the subject of intense study and it has become evident that cellmediated perturbations in elastic fibre homeostasis, as a result of ROS-induced tropoelastin and MMP transcription (Wlaschek et al 2001), contribute to tissue ageing. In addition to these cell-mediated anabolic and catabolic mechanisms, ROS are known to act directly on ECM collagens (Verzijl et al 2000), but the influence of oxidation on the structure and function of elastic fibre components remains poorly understood.…”
Section: Degradationmentioning
confidence: 99%
“…Superimposed on this intrinsic process, extrinsic ageing is related to UV-induced damage of the dermis (photoageing) [60]. Cellular changes as well as qualitative and quantitative alterations of dermal extracellular matrix proteins are involved, resulting in dyspigmentation, loss of recoil capacity and tensile strength with wrinkle formation, increased fragility, impaired wound healing and malignancies [61,62]. Alterations in collagen, the major structural component of the skin, have been considered to be a cause of skin ageing and are observed in naturally aged and photoaged skin [63].…”
Section: Ecm1 Expression Is Altered In Skin Age-ingmentioning
confidence: 99%
“…Structural components of the extracellular matrix such as interstitial collagen and elastin are reduced and the content of cross-links in collagen fibers is increased, which increases stiffness of the skin. Aged skin is also typified by an enhanced release of matrix-degrading metalloproteases [62,63,65], which results in a decreased level of ECM and reduced elastin and fibrillin-1 expression.…”
Section: Ecm1 Expression Is Decreased In Chronological Ageingmentioning
confidence: 99%
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