2001
DOI: 10.1111/j.1349-7006.2001.tb01081.x
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Sole Expression of Laminin γhain in Invading Tumor Cells and Its Association with Stromal Fibrosis in Lung Adenocarcinomas

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Cited by 51 publications
(50 citation statements)
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“…A plethora of putative prognostic markers have been identified, but most have not been independently validated. We and others 5,6 demonstrated that LAMC2 protein expression correlated well with clinical outcome of stage I ADC patients, which was further supported by our functional studies in vitro and in vivo metastasis models. Moreover, it has been reported that serum LAMC2 exhibited diagnostic complementarity with CA19.9 in pancreatic ADC allowing earlier detection of primary or recurrent pancreatic cancer.…”
Section: Discussionsupporting
confidence: 85%
See 1 more Smart Citation
“…A plethora of putative prognostic markers have been identified, but most have not been independently validated. We and others 5,6 demonstrated that LAMC2 protein expression correlated well with clinical outcome of stage I ADC patients, which was further supported by our functional studies in vitro and in vivo metastasis models. Moreover, it has been reported that serum LAMC2 exhibited diagnostic complementarity with CA19.9 in pancreatic ADC allowing earlier detection of primary or recurrent pancreatic cancer.…”
Section: Discussionsupporting
confidence: 85%
“…It has been demonstrated that LAMC2 protein expression correlates with clinical outcome of stage I lung adenocarcinoma (ADC) patients. 5,6 In addition, noncontinuous expression pattern of LAMC2 predicts the prognosis of esophageal squamous cell carcinoma (SCC), 7 and secreted LAMC2 in the serum is associated with the aggressiveness of pancreatic cancer. 8 Besides, LAMC2 monomer expression has been frequently found in the invasive front of epithelial tumors such as ADCs of the stomach, colon, pancreas, and lung, SCCs of the esophagus, head and neck, skin and lung, and transitional cell carcinoma of the bladder.…”
mentioning
confidence: 99%
“…For example, in colon carcinoma, urinary bladder carcinoma, colorectal carcinoma, SCC of the oral cavity, tongue, skin, kidney, prostate, lung, vagina, hand and neck, gastric carcinoma, alveolar carcinoma, breast cancer, splenic carcinoma, cervical adenocarcinoma, esophageal carcinoma, adenoid cystic carcinoma, ductal tumor of the pancreas, glioma, clear cell carcinoma of the ovary, and epidermoid anal cancer, cells or tissues adjacent to the tumor front express the laminin γ2 chain or its fragment [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65]. The latter fragment is also known as the laminin γ2 short arm (SA) and includes an epidermal growth factor (EGF)-like domain.…”
Section: Section 2 Part 1: Changes In Laminin-332 Expression In Cancermentioning
confidence: 99%
“…[1][2][3] The laminin ␥2 chain is unique in the laminin 5 molecule, and laminin ␥2 chain expression has been associated with the invasion and metastasis of tumor cells. [11][12][13][14] In patients with colon and gastric carcinoma, overexpression of the laminin ␥2 chain has been observed in invading tumor cells. 8,11,15 It also has been reported that gastric carcinoma cells produce a high level of the laminin ␥2 chain monomer in vitro.…”
mentioning
confidence: 99%