Solid and Papillary Epithelial Neoplasm of the Pancreas An Ultrastructural and Immunocytochemical Study of Six Cases

Lieber, Michael R.; Lack, Ernest E.; Roberts, John R.; Merino, María J.; Patterson, Kathleen; Restrepo, Carlos; Solomon, Diane; Chandra, Roma; Triche, Timothy J.

doi:10.1097/00000478-198702000-00001

Cited by 135 publications

(58 citation statements)

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“…Complications due to SPN are rare and usually reflect local compression of the surrounding structures rather than invasion. Reports highlight obstructive jaundice [9], invasion or compression of the portal vein [17,20], other vessels [18,34] and invasion of the duodenum [17,20], stomach [29] or spleen [20,30,31] as in our case. Rupture of the tumour occurred in 2.3% of the reported cases.…”

Section: Discussionmentioning

confidence: 66%

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Solid Pseudopapillary Neoplasm of the Pancreas: Report of a Case after a 10-Year Follow-Up and Review of the Literature

et al. 2001

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Section: Discussionmentioning

confidence: 66%

“…Four patients with a follow-up of ! 5 years were alive with the tumour [27][28][29]. One patient died of the disease within the first 5 years after operation [21], and 2 patients with tumour died of unrelated causes [18].…”

Section: Introductionmentioning

confidence: 99%

Solid Pseudopapillary Neoplasm of the Pancreas: Report of a Case after a 10-Year Follow-Up and Review of the Literature

et al. 2001

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“…169,170,173,175,178 Most cases are quite large at diagnosis (mean diameter of 9-10 cm), although with the increased use of crosssection imaging techniques, more cases are being diagnosed when less than 5 cm. 179,180 Grossly, solidpseudopapillary neoplasms appear to be circumscribed or even partially encapsulated. The larger examples are particularly prone to develop degenerative cystic changes, and near complete cystic change may occur, simulating a pseudocyst.…”

Section: Solid-pseudopapillary Neoplasmmentioning

confidence: 99%

“…Solid sheets of uniform polygonal cells are separated into nests by abundant capillarysized vessels (Figure 18). 178,179,181,182 There is no true lumen formation. The cells are relatively discohesive, and in areas away from the vessels, cell drop away, leaving a ragged cuff of neoplastic cells clinging to the blood vessels; this results in the characteristic pseudopapillae (Figure 19).…”

Section: Solid-pseudopapillary Neoplasmmentioning

confidence: 99%

Nonductal neoplasms of the pancreas

2007

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Although the majority of pancreatic neoplasms are infiltrating ductal adenocarcinomas or other neoplasms with ductal differentiation, neoplasms with acinar, endocrine, mixed, or uncertain differentiation constitute a diverse and distinctive group. The most common and best-characterized nonductal neoplasms are pancreatic endocrine neoplasm, acinar cell carcinoma, pancreatoblastoma, and solid pseudopapillary neoplasm. This review details the clinical and pathologic features of these nonductal neoplasms, highlighting diagnostic criteria including the use of specific immunohistochemical stains to define the cellular differentiation of the neoplasms. Modern Pathology (2007) 20, S94-S112.

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“…SPT is the most recent name advocated by the WHO 83,84 for a distinctive tumor type in the pancreas that often presents as a cystic mass, and for this reason was previously (and is sometimes still) referred to as 'solid and cystic', 185,186 'solid and papillary' 187 'cystic and papillary' and 'papillarycystic'. 188,189 The plethora of names used previously for SPT reflects the enigmatic nature of this neoplasm.…”

Section: Solid-pseudopapillary Tumor (Spt)mentioning

confidence: 99%

Cystic lesions of the pancreas

Adsay

2007

Modern Pathology

191

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Although cystic tumors of the pancreas are relatively rare, they constitute an increasingly important category. Advances in imaging and interventional techniques and the sharp drop in the mortality rate of pancreatic surgery have rendered pancreatic biopsies and resections commonplace specimens. Consequently, in the past two decades, the nature of many cystic tumors in this organ has been better characterized. The names of some existing entities were revised; for example, what was known as papillary-cystic tumor is now regarded as solidpseudopapillary tumor. New entities, in particular, intraductal papillary mucinous neoplasm and its variants, such as oncocytic and intestinal subtypes were recognized. The importance of clinical and pathologic correlation in the evaluation of these lesions was appreciated, in particular, with regards to the multifocality of these lesions, their association with invasive carcinomas, and thus their 'preinvasive' nature. Consensus criteria for the distinction of these from the ordinary precursors of adenocarcinoma, the pancreatic intraepithelial neoplasia, were established. The definition of mucinous cystic neoplasms was refined; ovarian-like stroma has now become almost a requirement for the diagnosis of mucinous cystic neoplasia, and defined as such, the propensity of these tumors to occur in perimenopausal women became even more striking. The validity and clinical value of classifying the pancreatic cysts of mucinous type as adenoma, borderline, CIS and invasive have been established. Related to this, the importance of thorough sampling in accurate classification of these mucinous lesions was recognized. Greater accessibility of the pancreas afforded by improved invasive as well as noninvasive modalities has also increased the detection of otherwise clinically silent cystic tumors, which has led to the recognition of more innocuous entities such as acinar cell cystadenoma and squamoid cyst of pancreatic ducts. As the significance of the cystic lesions emerged, cystic forms of otherwise typically solid tumors were also better characterized. Thus, significant developments have taken place in the classification and our understanding of pancreatic cystic tumors in the past few years, and experience with these lesions is likely to grow exponentially in the coming years. Modern Pathology (2007) 20, S71-S93.

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Solid and Papillary Epithelial Neoplasm of the Pancreas An Ultrastructural and Immunocytochemical Study of Six Cases

Cited by 135 publications

References 0 publications

Solid Pseudopapillary Neoplasm of the Pancreas: Report of a Case after a 10-Year Follow-Up and Review of the Literature

Solid Pseudopapillary Neoplasm of the Pancreas: Report of a Case after a 10-Year Follow-Up and Review of the Literature

Nonductal neoplasms of the pancreas

Cystic lesions of the pancreas

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