Solid and papillary epithelial neoplasm of the pancreas: imaging-pathologic correlation on 56 cases.

Abstract

Imaging studies of SPEN of the pancreas consistently demonstrate variable degrees of hemorrhagic degeneration. Calcification is common. Characteristic fluid-debris levels and signal intensities seen with MR imaging indicate blood products. In the appropriate clinical setting, these findings are useful in making a prospective diagnosis.

Solid pseudopapillary neoplasm of the pancreas: CT imaging features and radiologic-pathologic correlation

“…The degenerate tumor tissue can undergo dystrophic calcification (14). Between 29% and 65% of SPNs are reported to have calcification (5,11). Calcification of the fibrous pseudocapsule is not uncommon.…”

Nonductal neoplasms of the pancreas

“…4,169,170 These tumors predominantly affect females (89% female), with a mean age of 28 years (range of 7-79 years). Most patients present with nonspecific symptoms related to the intra-abdominal mass, 169,[171][172][173] and a palpable mass or incidental radiographic finding may be the route of tumor discovery in asymptomatic individuals. Rarely solid-pseudopapillary neoplasms rupture, causing potentially life-threatening hemoperitoneum.…”

A Case of Solid Pseudopapillary Neoplasm of the Pancreas Presenting with Left-sided Extrahepatic Portal Hypertension

“…It is likely that the splenic phlebitis resulted in various compensatory changes including collateral drainage through the short gastric veins, which subsequently resulted in engorgement of the vessels along the gastric body wall and the formation of gastric varices. The present patient had a typical SPN based on both imag-ing and pathological findings (11,15,16). The CT showed a large encapsulated mass with variable solid and cystic components caused by hemorrhagic degeneration.…”

“…As one would expect in a neoplasm with β-catenin activation, cyclin D1 overexpression has also been reported in the majority of SPN (10). Since most of these tumors are benign, the prognosis after excision is good (11)(12)(13). SPN is often detected when patients present with abdominal pain or an abdominal mass.…”