Solid Contact Ion‐selective Electrodes on Printed Circuit Board with Membrane Displacement

Zhang, Zhehao; Papautsky, Ian

doi:10.1002/elan.202100686

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…For example, Steinsberger et al demonstrated a RuO 2 electrode for pH measurements, while Chen et al reported an IrO x electrode . However, while we have used a similar approach in the past with ion selective electrodes, adopting this approach herein would necessitate the use of custom microfluidic cells and would make the instrument setup more complex. The titration process end point determination can be also done spectrometrically using a combination of an LED and a photodiode. ,, This approach, however, also requires the development of custom flow cell setups and integration with optical devices.…”

Section: Resultsmentioning

confidence: 99%

Automatic Microtitrator for Small Volume Samples

Rehman

Zhang

et al. 2022

ACS Meas. Sci. Au

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Electroanalytical sensors for point-of-care biomedical or point-of-use environmental sample analysis are gaining popularity due to low limits of detection, ease of miniaturization, convenience, and ability to work with small sample volumes. Since pH must be tightly controlled for optimum electrochemical performance, adjustment of pH in these samples is often a necessity. Yet manual titration is time-consuming and can be especially challenging for small volumes. End point determination can also be difficult. Current commercial automatic pH titrators are generally designed for large volume (>1 mL) batch titrations, while the existing microvolume titrators are semiautomatic at best, still relying on multiple manual steps. To address the gap, we developed an automatic microtitration system suitable for small volume samples. The system was validated using digested whole blood microsamples, successfully demonstrating accurate and rapid pH adjustment for samples as small as 100 μL. The simple modular construction of the system makes it compatible with acid washing for trace metal detection and other cleaning or sample preparation steps. The electrochemical detection of manganese heavy metal in blood at the parts per billion level showed no detectable contamination induced by the system. Ultimately, our simple, accurate, user-friendly automatic microtitration system can be used in the pH adjustment of microvolume samples and can potentially be extended to other pH end point analysis.

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Section: Resultsmentioning

confidence: 99%

Automatic Microtitrator for Small Volume Samples

Rehman

Zhang

et al. 2022

ACS Meas. Sci. Au

Self Cite

View full text Add to dashboard Cite

show abstract

“…4 shows the main steps for preparing the TMA sensor, its morphological image, as well as photos of the portable sensing device. Carbon black has also been used as a solid contact in SC-ISEs for the determination of Na + , K + , NO 3 − , and acetylcholine, 103–108 exhibiting a Nernstian response with low LODs.…”

Section: Applications Of Nanomaterial-based Sc-isesmentioning

confidence: 99%