A hybrid solid desiccant cooling system (SDCS), which combines a solid desiccant system and a vapor compression system, is considered to be an excellent alternative for commercial and residential air conditioning systems. In this study, a solar-assisted hybrid SDCS system was developed in which solar-heated water is used as an additional heat source for the regeneration process, in addition to recovering heat from the condenser of an integrated heat pump. A solar thermal collector sub-system is used to generate solar regeneration water. Experiments were conducted in the typically hot and humid weather of Taichung, Taiwan, from the spring to fall seasons. The experimental results show that the overall performance of the system in terms of power consumption can be enhanced by approximately 10% by integrating a solar-heated water heat exchanger in comparison to the hybrid SDCS system. The results show that the system performs better when the outdoor humidity ratio is large. In addition, regarding the effect of ambient temperature on the coefficient of performance (COP) of the systems, a critical value of outdoor temperature exists. The COP of the systems gradually rises with the increase in ambient temperature. However, when the ambient temperature is greater than the critical value, the COP gradually decreases with the increase in ambient temperature. The critical outdoor temperature of the hybrid SDCS is from 26 °C to 27 °C, and the critical temperature of the solar-assisted hybrid SDCS is from 27 °C to 30 °C.