Solid dispersion: application and limitations

Abstract

Solubility and dissolution rate are essential factors in the bioavailability of a drug. The drug must be well-soluble in water to have good bioavailability. Solid dispersion is among the most widely used and effective methods for increasing solubility and releasing inadequately water-soluble medications. Solid dispersion requires the choice of a suitable carrier for the right active pharmaceutical ingredients and the proper techniques for preparing solid dispersions. The reliable dispersion system is designed in various ways to achieve the goal and avoid the accompanying obstacles.
 Keywords: solid dispersion, solubility, solvent evaporation, lyophilization, generation, methods