Solid dispersion matrix tablet comprising indomethacin-PEG-HPMC fabricated with fusion and mold technique

Mesnukul, Anongnart; Yodkhum, Kotchamon; Phaechamud, Thawatchai

doi:10.4103/0250-474x.57290

Cited by 26 publications

(9 citation statements)

References 33 publications

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“…Tablets containing 75-mg indomethacin, PEG4000:PEG400 (7:3) and different amount of xanthan gum were prepared using the melting and mold technique with the stainless steel mold with diameter and height of 12 mm and 6.8 mm, respectively, as described in the previous report[ 8 ].…”

Section: Methodsmentioning

confidence: 99%

“…Drug release from these tablets was compared to capsule containing 75-mg indomethacin powder. Least square fitting of the experimental dissolution data to the mathematical equations (power law, first-order, Higuchi's and zero-order) was carried out with the same method as previously described[ 8 12 ].…”

Section: Methodsmentioning

confidence: 99%

“…Swelling behavior of the tablets was investigated through textural analysis as described in the previous report[ 8 14 ]. Briefly, tablets were placed in the dissolution vessels under condition identical to that described above for dissolution testing.…”

Section: Methodsmentioning

confidence: 99%

“…In particular, solid polyethylene glycols (PEGs) have been employed as carriers for increasing the dissolution rate of several poorly water-soluble drugs[ 3 – 7 ]. PEG has potentially been utilized as a matrix component prepared with fusion and mold method[ 8 ]. All grades of PEG are miscible in all proportions with other PEGs.…”

mentioning

confidence: 99%

“…Both the enhancement of dissolution and the prolonged drug release of indomethacin could be achieved by addition of hydroxypropylmethylcellulose into PEG matrix system[ 8 ]. From that previous report the least square curve fitting indicated that the drug liberated from this matrix system conformed to an anomalous transport.…”

mentioning

confidence: 99%

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Characterization of indomethacin release from polyethylene glycol tablet fabricated with mold technique

Mesnukul¹,

Yodkhum²,

Mahadlek³

et al. 2010

Indian J Pharm Sci

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The purpose of this study was to use polyethylene glycol as a carrier to improve the solubility of an aqueous insoluble drug by melting and molding method. The release of dissolved drug was designed to be subsequently sustained with an addition of xanthan gum. The release of indomethacin from the developed system into phosphate buffer pH 6.2 was conducted using the dissolution apparatus. This carrier system could effectively enhance the solubility of indomethacin and an addition of xanthan gum could sustain the drug release. Eudragit L100 film coating could protect the carrier not to be disturbed with HCl buffer pH 1.2 and could dissolve in phosphate buffer pH 6.2, therefore, the drug release from coated tablet was initially very low but subsequently gradually released and prolonged in phosphate buffer pH 6.2. Differential scanning calorimetry study indicated the amorphous state of drug in polyethylene glycol carrier. Scanning electron microscopy photomicrograph indicated the drug diffusion outward through the porous network of matrix tablets into the dissolution fluid and curve fitting signified that the drug release kinetic was Fickian diffusion.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Characterization of indomethacin release from polyethylene glycol tablet fabricated with mold technique

Mesnukul¹,

Yodkhum²,

Mahadlek³

et al. 2010

Indian J Pharm Sci

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Synthesis of Crosslinked Hydroxypropyl Methylcellulose with Methyl Gallate‐Poly(Ethylene Glycol) as a Gel Electrolyte for Dye‐Sensitized Solar Cells

Gunasekaran

Sorrentino

Aljafari

et al. 2023

Physica Status Solidi (a)

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Hydroxypropyl methylcellulose (HPMC) is blended with methyl gallate (MG) encapsulated with poly(ethylene glycol) (PEG) and then mixed with a liquid electrolyte to prepare a polymer gel electrolyte. The structural and physical properties of prepared polymer gels are analyzed by various analytical instruments. The MG‐PEG‐HPMC hybrid is found to be able for entrapping a large amount of liquid electrolyte and is used to fabricate dye‐sensitized solar cells (DSSCs). This polymer gel electrolyte shows high ionic conductivity (5.43 × 10−4 S cm−1) and good triiodide diffusion coefficient (2.25 × 10−6 cm2 s−1). The resulting DSSCs show an efficiency of 6.96% at a light intensity of 85 mW cm−2. The long‐term stability test reveals that the fabricated DSSCs will be stable even after 500 h. The benefits of incorporating a gel electrolyte into DSSCs are highlighted along with factors affecting the stability of these devices. The use of these bio‐based materials has the potential to make a significant contribution to the widespread exploitation of stable, efficient, and low‐cost dye‐sensitive solar cells.

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Facile synthesis and in vitro evaluation of semi-interpenetrating polymeric network

et al. 2022

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Solid dispersion matrix tablet comprising indomethacin-PEG-HPMC fabricated with fusion and mold technique

Cited by 26 publications

References 33 publications

Characterization of indomethacin release from polyethylene glycol tablet fabricated with mold technique

Characterization of indomethacin release from polyethylene glycol tablet fabricated with mold technique

Synthesis of Crosslinked Hydroxypropyl Methylcellulose with Methyl Gallate‐Poly(Ethylene Glycol) as a Gel Electrolyte for Dye‐Sensitized Solar Cells

Facile synthesis and in vitro evaluation of semi-interpenetrating polymeric network

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