Solid dispersions of oxazepam

Jachowicz, Renata; Nürnberg, E.; Hoppe, Ralph

doi:10.1016/0378-5173(93)90375-p

Cited by 22 publications

(7 citation statements)

References 5 publications

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“…Solid dispersions are formulated to enhance solubility of drug and in consequence to improve its bioavailability (Jachowicz, Nurnberg, & Hoppe, 1993).…”

Section: Solid Dispersionsmentioning

confidence: 99%

Unified methodology of neural analysis in decision support systems built for pharmaceutical technology

Mendyk

Jachowicz

2007

Expert Systems with Applications

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“…Solid dispersions are formulated to enhance solubility of drug and in consequence to improve its bioavailability (Jachowicz, Nurnberg, & Hoppe, 1993).…”

Section: Solid Dispersionsmentioning

confidence: 99%

Unified methodology of neural analysis in decision support systems built for pharmaceutical technology

Mendyk

Jachowicz

2007

Expert Systems with Applications

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“…The dissolution and thus bioavailability of drugs such as griseofulvin [94][95][96][97][98][99][100][101][102], nifedipine [103][104][105][106][107], felodipine [108][109], oxazepam [98][99][110][111][112] and diazepam [113] are limited by their poor state of aqueous solubility. This leads to a rising interest to design solid dispersion whereby one or more active ingredients are embedded in an inert solid matrix by the melting [94-95, 100-102, 105-107, 113-117], solvent [94-95, 100, 103-105, 108-109, 111-113, 115, 117] or melting-solvent method [94,115,117].…”

Section: Solid Dispersion/nanomatrixmentioning

confidence: 99%

Use of Microwave in Processing of Drug Delivery Systems

Wong

2008

CDD

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Microwave has received a widespread application in pharmaceuticals and food processing, microbial sterilization, biomedical therapy, scientific and biomedical analysis, as well as, drug synthesis. This paper reviews the basis of application of microwave to prepare pharmaceutical dosage forms such as agglomerates, gel beads, microspheres, nanomatrix, solid dispersion, tablets and film coat. The microwave could induce drying, polymeric crosslinkages as well as drug-polymer interaction, and modify the structure of drug crystallites via its effects of heating and/or electromagnetic field on the dosage forms. The use of microwave opens a new approach to control the physicochemical properties and drug delivery profiles of pharmaceutical dosage forms without the need for excessive heat, lengthy process or toxic reactants. Alternatively, the microwave can be utilized to process excipients prior to their use in the formulation of drug delivery systems. The intended release characteristics of drugs in dosage forms can be met through modifying the physicochemical properties of excipients using the microwave.

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“…5. Vacuum drying, 16,17) spray drying, [18][19][20][21] spraying on sugar beads using a fluidized bed-coating system, 22) lyophilization 23) etc. used for the removal of organic solvents from SDs further make it tedious, costly and most reports did not address how much residual solvents were present in SDs when different solvents, carriers, or drying techniques were used.…”

mentioning

confidence: 99%

Preparation, Characterization and Evaluation of Coenzyme Q10 Binary Solid Dispersions for Enhanced Solubility and Dissolution

Bhandari

Newa

Kim

et al. 2007

Biological & Pharmaceutical Bulletin

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Coenzyme Q10 (CoQ10) (Fig. 1), a yellow crystalline powder with a melting point of about 50°C is a lipid soluble vitamin like substance that inhabits inside of the inner mitochondrial membrane where it functions as an integral part of electron transport of oxidative phosphorylation.1) It is used as a nutritional supplement, antioxidant and in the treatment of cardiovascular disorders such as angina pectoris, hypertension, and congestive heart failure. It is practically insoluble in water and poorly absorbed (T max 5-10 h) from the gastrointestinal tract due to its high molecular weight and poor water solubility thereby presenting a challenge in the development of a formulation for oral administration.2) Many approaches for formulating CoQ10 have been reported. Oil based or powder filled capsules and tablet formulations are currently available on the market as nutritional supplements.3,4) However, dissolution and oral bioavailability of these formulations differ widely.5) Other reported formulation strategies include a solubilized system with soy lecithin, 6) a micellar solution of CoQ10 with polyoxyethylene (60) hydrogenated castor oil, 7) lipid microspheres prepared as a soybean oil emulsified with yolk phospholipids, 8) a redispersible dry emulsion, 9) the complexation of CoQ10 with cyclodextrins, 10) self-emulsifying drug delivery systems, 3) and a solubilized form of CoQ10 in a blend of polysorbate 80 and medium chain triglycerides.11) However, dissolution profiles are not reported for most of these formulations either due to their oily nature and poor aqueous solubility or due to the absence of a suitable dissolution medium. Further, these approaches were tedious, time consuming and costly. Thus, there is a great need for an efficient, easy, quick, and costeffective method to improve the solubility and dissolution of CoQ10.Dispersion of poorly water soluble drug in an inert hydrophilic carrier matrix at solid state either by melting or solvent or solvent-melting method leads to products known as solid dispersions (SD) 12,13) that have tremendous potential for improving drug solubility 14,15) because of the drug solubilizing or co-solvent effect of hydrophilic carrier, better wettability and dispersibility of drug by the carrier material, and the formation of amorphous forms of drug and carriers. [12][13][14][15] However, the SDs prepared by high temperature melting, solvent or solvent-melting method etc. are problematic because 1. The high melting temperatures could chemically decompose drugs and carriers, 12) 2. The hardening of melts could lead to difficulties in pulverization for subsequent formulation into an appropriate dosage form, 3. It is difficult to identify a common solvent to dissolve hydrophobic drug and hydrophilic carrier, 4. The large volumes of solvents and heating are necessary to enable complete dissolution of both components. 5. Vacuum drying, 16,17) spray drying, [18][19][20][21] spraying on sugar beads using a fluidized bed-coating system, 22) lyophilization 23) etc. used for the remov...

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Solid dispersions of oxazepam

Cited by 22 publications

References 5 publications

Unified methodology of neural analysis in decision support systems built for pharmaceutical technology

Unified methodology of neural analysis in decision support systems built for pharmaceutical technology

Use of Microwave in Processing of Drug Delivery Systems

Preparation, Characterization and Evaluation of Coenzyme Q10 Binary Solid Dispersions for Enhanced Solubility and Dissolution

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