Solid/Hollow Depots for Drug Delivery, Part 1: Effect of Drug Characteristics and Polymer Molecular Weight on the Phase-Inversion Dynamics, Depot Morphology, and Drug Release

Liu, Hui; Venkatraman, Subbu S.

doi:10.1002/jps.23790

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…and ). A similar observation has been described in previous studies . We hypothesize that the development of this macroscale feature occurs as a result of autocatalytic degradation and can be explained with percolation theory .…”

Section: Discussionsupporting

confidence: 90%

“…A number of methods have been used to control the release profile of phase‐sensitive ISFIs, typically by altering the mass transfer kinetics of the solvent/nonsolvent in order to increase or decrease the porosity of the polymer matrix . Factors such as changes in the polymer molecular weight (MW), concentration of the casting solution, or the solvent composition have all been successfully used to change the release profile of the implant . However, these changes often result in an increased solution viscosity that can limit the injectability of the solution .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants

Solorio

Sundarapandiyan

Olear

et al. 2015

Journal of Pharmaceutical Sciences

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Phase sensitive in situ forming implants (ISFI) are a promising platform for the controlled release of therapeutic agents. The simple manufacturing, ease of placement, and diverse payload capacity make these implants an appealing delivery system for a wide range of applications. Tailoring the release profile is paramount for effective treatment of disease. In this study, three innovative formulation modifications were used to control drug release. Specifically, water, 1,1’-dioctadecyl-3,3,3’,3’-tetramethylindocarbocyanine perchlorate (DiI), and bovine serum albumin (BSA) were incorporated into an ISFI solution containing the small molecular weight mock drug, sodium fluorescein. The effects of these additives on drug release, swelling, phase inversion, erosion, and implant microstructure were evaluated. Diagnostic ultrasound was used to monitor changes in swelling and phase inversion over time noninvasively. Water, DiI, and the combination of BSA/DiI functioned to reduce burst release 47.6%, 76.6%, and 59.0% respectively. Incorporation of water into the casting solution also enhanced the release of drug during the diffusion period of release by 165.2% relative to the excipient free control. Incorporation of BSA into the polymer solution did not significantly alter the burst release (P<0.05), however the onset of degradation facilitated release was delayed relative to the excipient free control by 5 d. This study demonstrates that the use of excipients provides a facile method to tailor the release profile and degradation rate of implants without changing the polymer or solvent used in the implant formulation, providing fine control of drug dissolution during distinct phases of release.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants

Solorio

Sundarapandiyan

Olear

et al. 2015

Journal of Pharmaceutical Sciences

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show abstract

“…Nanosized drug depots, in which a drug reservoir is surrounded by pharmaceutical excipients, have attracted much attention in the biomedical field recently [1][2][3][4][5][6]. They have been explored for drug delivery through a variety of administration routes (such as oral, injected, inhaled, and implanted) and also as stents in tissue engineering [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

Yang

et al. 2017

Acta Biomaterialia

124

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Nanosized sustainedrelease drug depots fabricated using modified tri-axial electrospinning, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.01.069 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning Abstract:Nanoscale drug depots, comprising a drug reservoir surrounded by a carrier membrane, are much sought after in contemporary pharmaceutical research. Using cellulose acetate (CA) as a filament-forming polymeric matrix and ferulic acid (FA) as a model drug, nanoscale drug depots in the form of core-shell fibers were designed and fabricated using a modified tri-axial electrospinning process. This employed a solvent mixture as the outer working fluid, as a result of which a robust and continuous preparation process could be achieved. The fiber-based depots had a linear morphology, smooth surfaces, and an average diameter of 0.62 ± 0.07 µm. Electron microscopy data showed them to have clear core-shell structures, with the FA encapsulated inside a CA shell. X-ray diffraction and IR spectroscopy results verified that FA was present in the crystalline physical form. In vitro dissolution tests revealed that the fibers were able to provide close to zero-order release over 36 h, with no initial burst release and minimal tailing-off. The release properties of the depot systems were much improved over monolithic CA/FA fibers, which exhibited a significant burst release and also considerable tailing-off at the end of the release experiment. Here we thus demonstrate the concept of using modified tri-axial electrospinning to design and develop new types of heterogeneous nanoscale biomaterials.

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Effects of polymer molecular weight on in vitro and in vivo performance of nanoparticle drug carriers for lymphoma therapy

You

Wang

Zhang

et al. 2023

Chinese Chemical Letters

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Solid/Hollow Depots for Drug Delivery, Part 1: Effect of Drug Characteristics and Polymer Molecular Weight on the Phase-Inversion Dynamics, Depot Morphology, and Drug Release

Cited by 4 publications

References 36 publications

The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants

The Effect of Additives on the Behavior of Phase Sensitive In Situ Forming Implants

Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning

Effects of polymer molecular weight on in vitro and in vivo performance of nanoparticle drug carriers for lymphoma therapy

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