Solid Lipid Based Nano-particulate Formulations in Drug Targeting

Abstract

Recently, targeted drug delivery systems have gained much more interest for delivering varieties of drugs as well as imaging agents specifically to the targeted disease cells or tissues. These are well known for their increased precision and accuracy in mode of drug delivery along with reduced side effects. Though numerous carriers are being employed for drug targeting, the solid lipid based nanoparticles (SLNs) are preferred over them owing to their ability to encapsulate wide varieties of drugs, biocompatibility, ease of surface modification, scaling up feasibility, and possibilities of both active as well as passive targeting to various organs. Surface of these drug loaded SLNs can be modified by conjugating different ligands to enhance their tissue/organ targeting ability and therapeutic efficacy to much higher extent. In this chapter, we have discussed about the SLNs and their different surface modified forms for passive as well as active targeting to different organ such as (colon, breast, lungs, liver, kidney, brain, eyes, etc.) in combating different diseases.

In vivo pharmacodynamics of lactoferrin-coupled lipid nanocarriers for lung carcinoma: intravenous versus powder for inhalation

“…It was reported that lung targeting in speci c "the deep lung" confronts a crucial challenge, namely the premature mucocilliary clearance. Ligand-anchored drug delivery system aim at achieving enhanced sitespeci c drug delivery as well as reduced reticular endothelial system (RES) uptake [6,7] . However, the clinical success of such an approach depends on the selection of appropriate ligands lacking immunogenic potential with the ability to mediate cargo internalization by the target cell [8] .…”