Solid lipid microparticles produced by spray chilling technique to deliver ginger oleoresin: Structure and compound retention

Oriani, Vivian Boesso; Alvim, Izabela Dutra; Consoli, Larissa; Molina, Gustavo; Pastore, Gláucia Maria; Hubinger, Míriam Dupas

doi:10.1016/j.foodres.2015.12.015

Cited by 53 publications

(30 citation statements)

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“…The particle was dispersed in absolute ethyl alcohol and result was determined for an average fraction of 0.1000 g sample, making 5 readings for each measurement. The mean particle size was expressed as the average diameter of a sphere of the same volume (De Brouckere diameter -D [4,3] ), and the polydispersity was given by the span index, which was calculated according to Equation 2 (Sartori et al, 2015;Alvim et al, 2016;Driani et al, 2016).…”

Section: Particle Size Distributionmentioning

confidence: 99%

“…Desai & Park (2005) mention other advantages regarding the conversion of liquid materials into dry powdered form without additional drying, and direct tableting characteristics of the co-crystallized products due to their agglomerated structure, finding wide application in candy and pharmaceutical industries. Driani et al (2016) proposed other technique through spray chilling to deliver ginger oleoresin in solid microparticles. Munin & Edwards-Lévy (2011) and Fang & Bhandari (2010) published reviews focused on different techniques to encapsulation of polyphenols and commented that the main advantages of the co-crystallization technique are that the granular product obtained possesses a very low hygroscopicity, good fluidity, and better stability.…”

Section: Introductionmentioning

confidence: 99%

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Co-crystallization of paprika oleoresin and storage stability study

et al. 2019

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Paprika oleoresin was co-crystallized to formulate a natural and hydrophilic dye for use in food applications. The color stabilities of the co-crystallized and free oleoresins were evaluated at different temperatures (25 and 35 °C, 70% RH) and light exposures (light 70 watts and dark, 25 °C, 70% RH). Co-crystallization from supersaturated sucrose syrup (S = 1.32) was found to be optimum for the formation of sugar agglomerates in a few minutes, with the paprika oleoresin entrapped inside. With time, decreases in the values of the a* parameter and the β-carotene content were observed with increasing temperature and with the incidence of light. The color degradation kinetics were dependent on both factors. The loss of color was greater for the free oleoresin as compared to the co-crystallized, suggesting that the co-crystallization process improves oleoresin retention in the sugar matrix, making it less susceptible to losses due to color degradation.Practical Applications: Co-crystallization process was used to encapsulate paprika oleoresin in sucrose matrix having natural color as the main technological feature of the product and developing an ingredient with good properties for application in sugar products. This approach created an ingredient with a hydrophobic compound incorporated in a hydrophilic matrix. Ot is an alternative process to handle and entrap a range of ingredients, aiming to improve the stability of the encapsulated material. β-carotene had good storage stability and degradation kinetics provided information to determine best storage conditions.

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Section: Particle Size Distributionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Co-crystallization of paprika oleoresin and storage stability study

et al. 2019

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“…Los picos en 2926 y 2869 cm -1 se relacionan con vibraciones asimétricas y simétricas de extensión -C-H del grupo metileno, respectivamente. La banda centrada en 1746 cm 1 refleja la absorbancia del grupo carbonilo -C=0, característica del grupo éster en los triglicéridos (Oriani et al 2016).…”

Section: Estudio Ftirunclassified

Oleorresina De Copaiba Como Materia Prima Para La Producción De Biodiésel

Cubillos

Tobón

Chaparro

2018

Rev. Int. Contam. Ambie.

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Palabras clave: biocombustibles, transesterificación, propiedades térmicas, flujo en frío RESUMEN La investigación consistió en analizar el potencial de la oleorresina extraída del árbol Copaifera reticulata para la producción de biodiésel a partir del proceso de transesterificación. La caracterización incluyó el estudio de la fluidez a bajas temperaturas, la estabilidad oxidativa y la determinación de propiedades como viscosidad, índice de acidez y de fluidez, humedad, y punto de inflamación de la oleorresina tanto cruda como modificada por vía química. Se observó que la técnica empleada para la producción de biodiésel genera pérdidas de oleorresina, ya que el rendimiento global en la producción fue cercano al 10 %. Sin embargo, los procesos de refinado y transesterificación influyeron positivamente sobre la estabilidad oxidativa de la oleorresina. Respecto de la oleorresina cruda, la estabilidad de la oleorresina refinada y el biodiésel de copaiba se incrementaron en 46 y 47 ºC, respectivamente. De acuerdo con los puntos de fluidez, en todos los casos el comportamiento de flujo en frío supera significativamente los rangos establecidos. El biodiésel presentó un punto de fluidez inferior a-39 ºC. Según los valores de viscosidad y densidad, el uso de la oleorresina en sus formas cruda o modificado-aunque condicionado de forma directa-podría considerarse en mezclas con gasóleo u otros biocombustibles, a fin de mejorar sus propiedades a bajas temperaturas. Estudios posteriores permitirán establecer técnicas eficientes para la modificación química de la oleorresina.

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“…6-shogaol rich ginger oleoresin (6-SRGO) is an oleoresin isolated from Zingiber officinale Rosc., consisting of higher content of phenolic ketones; gingerols and shogaols [4][5][6]. Traditionally they are used for the treatment of a cough, stomach upset, inflammation, hair diseases [7], diarrhoea, nausea and vomiting.…”

Section: Introductionmentioning

confidence: 99%

6-Shogaol Rich Ginger Oleoresin Loaded Mixed Micelles Enhances in Vitro Cytotoxicity on McF-7 Cells and in Vivo Anticancer Activity Against Dal Cells

Kemkar

Lohidasan

Sathiyanarayanan

et al. 2018

Int J Pharm Pharm Sci

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Objective: Ginger oleoresin (GO) plays an important role on the attenuation of complications associated to the cancer which is attributed to 6-shogaol (6-SGL). The major challenge in using 6-SGL for therapeutic applications is its poor aqueous solubility, low stability in GI and low bioavailability. Considering the potent anticancer nature of 6-SGL and its synergistic activity with other constituents in GO, there is a need to develop a suitable drug delivery system. Methods:Thus in the present study, 6-SGL rich GO (6-SRGO) was incorporated into mixed micelles using phospholipid (Soya Lecithin) as a carrier. The prepared 6-SRGO loaded mixed micelles (6-SRGO-LMM) were characterized physically and chemically using Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and further evaluated for stability study, in vitro release study, in vitro cytotoxicity study and in vivo anticancer activity in comparison with 6-SRGO. Results:The composition such as, drug content (86.27±1.56), encapsulation efficiency (81.55±1.05) and particle size (356.11±4.07) were optimized using 3 2 Conclusion:We have developed and investigated mixed micelles composed of phospholipids (soya lecithin S80) and SCH as an effective nanocarrier for the delivery of a natural lipophilic anticancer bioactive 6-SGL from 6-SRGO. factorial design. FTIR and DSC study confirm that the 6-SGL from 6-SRGO was entrapped in the core of phospholipid by self-assembly method to form mixed micelles. The 6-SRGO-LMM exhibited significant in vitro (GI50-23.2 μg/ml) and in vivo anticancer activity in comparison with 6-SRGO.

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Solid lipid microparticles produced by spray chilling technique to deliver ginger oleoresin: Structure and compound retention

Cited by 53 publications

References 45 publications

Co-crystallization of paprika oleoresin and storage stability study

Co-crystallization of paprika oleoresin and storage stability study

Oleorresina De Copaiba Como Materia Prima Para La Producción De Biodiésel

6-Shogaol Rich Ginger Oleoresin Loaded Mixed Micelles Enhances in Vitro Cytotoxicity on McF-7 Cells and in Vivo Anticancer Activity Against Dal Cells

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