Solid Lipid Nanoparticles Enhanced the Neuroprotective Role of Curcumin against Epilepsy through Activation of Bcl-2 Family and P38 MAPK Pathways

Huang, Ruiqi; Zhu, Yanjing; Lin, Lijuan; Song, Simin; Cheng, Liming; Zhu, Rongrong

doi:10.1021/acschemneuro.0c00242

Cited by 34 publications

(11 citation statements)

References 55 publications

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“…In a kainic acid rat model, curcumin prevented activation of astrocytes and neuronal death, and a recent study showed a mechanism involving the Bcl2 family and P38 MAPK pathways (323). The anti-epileptic effects were probably associated, according to the authors, to lower IL10RB, CXCL17 and nicastrin levels.…”

Section: Epilepsymentioning

confidence: 91%

The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro¹,

Chiavaroli²,

Cicia³

et al. 2021

Pharm Adv

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Curcumin is the major phytoconstituent found in the rhizomes of Curcuma longa L. Preparations derived from the rhizome of the plant, referred as turmeric, have been used for centuries in the traditional Indian system of medicine. The recent literature has shown curcumin as one of the most interesting pleiotropic nutraceuticals capable of interacting with different molecular targets involved in chronic diseases. The present review summarizes and critically discusses the very recent literature published between 2018 and 2021. We focused on the preclinical pharmacological actions of curcumin in relation to its possible clinical application in several pathophysiological states and disturbances including inflammation and pain, as well as metabolic, cardiovascular, dermatological, and central nervous system diseases. The most relevant molecular targets of curcumin, such as transcription factors, pro-inflammatory mediators, enzymes, and protein kinase as well as pharmacokinetics in humans are also reviewed.

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Section: Epilepsymentioning

confidence: 91%

The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro¹,

Chiavaroli²,

Cicia³

et al. 2021

Pharm Adv

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“…In a mouse model of chronic epilepsy, the incorporation of curcumin with CS-alginate STPP NPs significantly increases its corresponding effects on cell death, cognitive defects, and glial activation, consistently with the solubility of the compound (Hashemian et al, 2017). Curcumin-loaded SL NPs induce neuroprotective effect by reducing apoptosis via upregulation of erythropoietin and klotho, reduction of tumor necrosis factor-α (TNF-α), and the subsequent activation of P38 MAPK pathways (Mansoor et al, 2018;Huang et al, 2020). It has also been shown that treatment with piperine-loaded CS-STPP NPs strongly inhibits the progression of epileptic symptoms by suppressing cell death and astrocyte stimulation compared to non-loaded piperine-treated mice (Anissian et al, 2018).…”

Section: Epilepsymentioning

confidence: 93%

The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders

Ngowi

Wang

Qian

et al. 2021

Front. Bioeng. Biotechnol.

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Brain is by far the most complex organ in the body. It is involved in the regulation of cognitive, behavioral, and emotional activities. The organ is also a target for many diseases and disorders ranging from injuries to cancers and neurodegenerative diseases. Brain diseases are the main causes of disability and one of the leading causes of deaths. Several drugs that have shown potential in improving brain structure and functioning in animal models face many challenges including the delivery, specificity, and toxicity. For many years, researchers have been facing challenge of developing drugs that can cross the physical (blood–brain barrier), electrical, and chemical barriers of the brain and target the desired region with few adverse events. In recent years, nanotechnology emerged as an important technique for modifying and manipulating different objects at the molecular level to obtain desired features. The technique has proven to be useful in diagnosis as well as treatments of brain diseases and disorders by facilitating the delivery of drugs and improving their efficacy. As the subject is still hot, and new research findings are emerging, it is clear that nanotechnology could upgrade health care systems by providing easy and highly efficient diagnostic and treatment methods. In this review, we will focus on the application of nanotechnology in the diagnosis and treatment of brain diseases and disorders by illuminating the potential of nanoparticles.

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“…The results of this study showed that this nanoliposome considerably enhanced the latency to the onset and reduced the duration of seizures in animal models of epilepsy and epileptic seizures. In another in vivo study, Huang, Lin, Chen, Chang, and Lin (2020) and Huang et al (2020) have reported antiepileptogenic effects of solid lipid nanocarriers containing Cur through reducing neuronal apoptosis, activation mechanisms of Bcl‐2 family, and P38 MAPK. These results indicated that this nanoformulation might be considered a promising therapeutic approach for the treatment of epilepsy.…”

Section: Cur Nanoformulations As Promising Strategies For the Treatme...mentioning

confidence: 99%

A comprehensive review of the therapeutic potential of curcumin nanoformulations

Khezri

Saeedi

Mohammadamini

et al. 2021

Phytotherapy Research

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Today, due to the prevalence of various diseases such as the novel coronavirus (SARS-CoV-2), diabetes, central nervous system diseases, cancer, cardiovascular disorders, and so on, extensive studies have been conducted on therapeutic properties of natural and synthetic agents. A literature review on herbal medicine and commercial products in the global market showed that curcumin (Cur) has many therapeutic benefits compared to other natural ingredients. Despite the unique properties of Cur, its use in clinical trials is very limited. The poor biopharmaceutical properties of Cur such as short half-life in plasma, low bioavailability, poor absorption, rapid metabolism, very low solubility (at acidic and physiological pH), and the chemical instability in body fluids are major concerns associated with the clinical applications of Cur.Recently, nanoformulations are emerging as approaches to develop and improve the therapeutic efficacy of various drugs. Many studies have shown that Cur nanoformulations have tremendous therapeutic potential against various diseases such as SARS-CoV-2, cancer, inflammatory, osteoporosis, and so on. These nanoformulations can inhibit many diseases through several cellular and molecular mechanisms. However, successful long-term clinical results are required to confirm their safety and clinical efficacy. The present review aims to update and explain the therapeutic potential of Cur nanoformulations.

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Solid Lipid Nanoparticles Enhanced the Neuroprotective Role of Curcumin against Epilepsy through Activation of Bcl-2 Family and P38 MAPK Pathways

Cited by 34 publications

References 55 publications

The pharmacological basis of the curcumin nutraceutical uses: an update

The pharmacological basis of the curcumin nutraceutical uses: an update

The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders

A comprehensive review of the therapeutic potential of curcumin nanoformulations

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