Solid lipid nanoparticles for targeted brain drug delivery☆

Functional Protein Delivery into Neurons Using Polymeric Nanoparticles

“…This is consistent with the observation that absorbed proteins can considerably influence the toxicity and distribution of nanomaterials in vivo and in vitro (58 -60). Although cytotoxicity of alkylcyanacrylate-based drug delivery systems has occasionally been reported (60,61), these effects are highly dependent on polymer alkyl side-chain length, and polymers with longer alkyl chains (like PBCA) demonstrate little toxicity toward multiple cell types (62,63). There is a report that PBCA NPs coated with Polysorbate 80 gain entry to the brain due to nonspecific opening of the BBB (64), although later findings suggest that no disruption of endothelial cell tight junctions nor nonspecific toxic effect occurs at therapeutic doses of the NPs (65).…”

“…There is a report that PBCA NPs coated with Polysorbate 80 gain entry to the brain due to nonspecific opening of the BBB (64), although later findings suggest that no disruption of endothelial cell tight junctions nor nonspecific toxic effect occurs at therapeutic doses of the NPs (65). Nevertheless, several surface modifications of polyalkylcyanoacrylate carriers continue to be explored in ongoing efforts to improve safety and biocompatibility (61,66).…”

Lovastatin Nanoparticle Synthesis and Characterization for Better Drug Delivery

“…These SLNs have their own merits, such as lower cytotoxicity, excellent physical stability, protection of incorporated labile drugs from degradation, controlled drug release (fast or sustained depending on the incorporation method), good tolerance, site-specific targeting, physico-chemical properties, and best production scalability [8]. The inborn potential demerits of these SLNs are insufficient drug loading capacity, drug expulsion after polymorphic transition during storage, and relatively high water content of the dispersions (70 -99.9%) [2,6,9,10]. The perfection in the resultant nanoparticles is mainly dependent on the lipid matrix composition.…”

“…This modification depends on change in temperature. More reports are available on these aspects for topical formulations [2,6,9,10]. Lipid emulsions (LEs), as reported, have been prepared using liquid lipids and coated with liquid emulsifiers.…”

“…The application of this technology improves the bioavailability, physico-chemical stability, and drug loading efficiency. Surface coating, nanoparticle fabrication, fundamental composition, and drug loading are critical factors that need to be considered during drug design [2,3]. Examples of this delivery system were successfully employed in the field of brain, cosmetic, dermal, bone fracture, and cancer target delivery [2][3][4][5].…”