Biotech drugs, including proteins, hormones, enzymes, DNA/RNA therapies, and
cell-based treatments, are gaining popularity due to their effectiveness. However, effective delivery
systems are needed to overcome administration challenges. Lipid nanoparticles (LNPs)
have emerged as promising carriers for various therapies. LNPs are biocompatible, less likely to
cause adverse reactions, and can stabilize delicate biological drugs, enhancing their stability and
solubility. Scalable and cost-effective manufacturing processes make LNPs suitable for largescale
production. Despite recent research efforts, challenges in stability, toxicity, and regulatory
concerns have limited the commercial availability of LNP-based products. This review explores
the applications, administration routes, challenges, and future directions of LNPs in delivering
biopharmaceuticals.