2014
DOI: 10.1016/j.ejpb.2013.08.013
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Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) for pulmonary application: A review of the state of the art

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Cited by 464 publications
(264 citation statements)
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“…The avoidance to use organic solvents and the use of GRAS elements is also of extreme importance and a great advantage concerning the no toxicity of these particles. The production methods are easy and inexpensive and can easily be scaled up to industrial production so as the sterilization method [98,100,[102][103][104][105].…”
Section: Solid Lipid Nanoparticles (Sln)mentioning
confidence: 99%
“…The avoidance to use organic solvents and the use of GRAS elements is also of extreme importance and a great advantage concerning the no toxicity of these particles. The production methods are easy and inexpensive and can easily be scaled up to industrial production so as the sterilization method [98,100,[102][103][104][105].…”
Section: Solid Lipid Nanoparticles (Sln)mentioning
confidence: 99%
“…30 SLNs provide the following advantages: physical stability, low cytotoxicity, protection of the incorporated drug from degradation, and controlled release. 31 Targeted drug delivery, which can carry drugs to specific organs or tissues, is another highly desirable treatment technique in cancer nanotechnology. [32][33][34] The cell-penetrating peptide (CPP) trans-activating transcriptional activator (TAT) is commonly used in payload delivery into cells both in the natural L-configuration and as a D-amino acid peptide.…”
mentioning
confidence: 99%
“…92,[99][100][101][102][103][104] Approximately 70% of the bioactive molecules incorporated into the mixture are well encapsulated into the carrier system and effectively reach the target site without much drop in bioactivity. 99,104,105 Solid phase lipids generally used to prepare nanostructured lipid carriers include acetyl alcohol, glycerol monosterate, and stearic acid and the liquid phase lipid includes caprylic …”
mentioning
confidence: 99%