Solid lipid nanoparticles (SLN) as potential carrier for human use: interaction with human granulocytes

Müller, Rainer H.; Maassen, Sjors; Schwarz, C.; Mehnert, W.

doi:10.1016/s0168-3659(97)01653-2

Cited by 92 publications

(31 citation statements)

References 15 publications

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“…[19,20] However, the cytotoxicity of the SLN in this study is comparable to the nanoparticulate systems consisting of polylactic acid/glycolic acid or polycyanocrylate nanoparticles. [21] 3.1. Morphological changes of the breast cancer cells treated with TAM, TAM-loaded SLN and SLN Apoptotic cell death can be recognised under phase contrast and fluorescence inverted microscope after staining.…”

Section: Resultsmentioning

confidence: 99%

Tamoxifen-loaded solid lipid nanoparticles-induced apoptosis in breast cancer cell lines

Abbasalipourkabir

Salehzadeh

Abdullah

2015

Journal of Experimental Nanoscience

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Section: Resultsmentioning

confidence: 99%

Tamoxifen-loaded solid lipid nanoparticles-induced apoptosis in breast cancer cell lines

Abbasalipourkabir

Salehzadeh

Abdullah

2015

Journal of Experimental Nanoscience

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“…Although both have the preparation methods, NLC may disrupt the crystal structure of regular solid lipid. When liquid lipid is added, it may cause irregular particle structure, increase the ratio of crystalline, and thus increase the encapsulation efficiency and drug loading [8,9]. The NLC system not only increases the stability of the compound, but also has good skin adhesion and bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method

Lin

Kuo

et al. 2017

Journal of Nanomaterials

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Nanostructured lipid carrier (NLC) was prepared by homogenization emulsification method and improved with modified surfactants. The properties of nanoparticles were investigated using the NLC system for hydroquinone (HQ) as a model drug and by increasing the light stability of hydroquinone. The optimized condition of NLC in stirring was 1200 rpm, the homogenized speed was 8000 rpm, solid oil to liquid oil ratio was 3 : 7, and lecithin to surfactant ratio was 3 : 1. The particle size was 393.30 ± 28.23 nm and the encapsulation efficiency was 22.13 ± 2.66%. The zeta-potential of HQ-NLC was better than −30 mV. In the thermogravimetric analysis (TGA) studies, adding of PLANTACARE 2000 UP for HQ-NLC has better heat resisting property than the HQ-NLC only. The addition of PLANTACARE 2000 UP to NLC shows better permeability (125.10%) than that of Blank. In the stability studies, the HQ-NLC after UVA/UVB irradiation has better inhibition rate (34.25%) than that of the Blank. In the present study, NLC system has successfully improved the light stability and the skin permeability of active compound. Therefore, the NLC might be a potential delivery vehicle for transdermal products in the future.

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“…They are used in cosmetics, textiles, bioimaging, medicine and diagno sis [1][2][3][4][5][6][7][8]. The widespread applications of NMs increase their chances of entering the human body via a number of pathways, such as the respi ratory system [9], skin absorption [10,11], intra venous injection [12] and implantation [13]. As a result, there is an urgent need to understand the potential physiological and patho logical reac tions after exposure to NMs [14,15].…”

Section: Reviewmentioning

confidence: 99%

Advances in The Understanding of Nanomaterial–Biomembrane Interactions and Their Mathematical and Numerical Modeling

Lin

et al. 2013

Nanomedicine

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The widespread application of nanomaterials (NMs), which has accompanied advances in nanotechnology, has increased their chances of entering an organism, for example, via the respiratory system, skin absorption or intravenous injection. Although accumulating experimental evidence has indicated the important role of NM–biomembrane interaction in these processes, the underlying mechanisms remain unclear. Computational techniques, as an alternative to experimental efforts, are effective tools to simulate complicated biological behaviors. Computer simulations can investigate NM–biomembrane interactions at the nanoscale, providing fundamental insights into dynamic processes that are challenging to experimental observation. This paper reviews the current understanding of NM–biomembrane interactions, and existing mathematical and numerical modeling methods. We highlight the advantages and limitations of each method, and also discuss the future perspectives in this field. Better understanding of NM–biomembrane interactions can benefit various fields, including nanomedicine and diagnosis.

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Solid lipid nanoparticles (SLN) as potential carrier for human use: interaction with human granulocytes

Cited by 92 publications

References 15 publications

Tamoxifen-loaded solid lipid nanoparticles-induced apoptosis in breast cancer cell lines

Tamoxifen-loaded solid lipid nanoparticles-induced apoptosis in breast cancer cell lines

Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method

Advances in The Understanding of Nanomaterial–Biomembrane Interactions and Their Mathematical and Numerical Modeling

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