SOLID LIPID NANOPARTICLES (SLNs) AS NANO DRUG DELIVERY CARRIERS: PREPARATION, CHARACTERIZATION AND APPLICATION

Qushawy, Mona; Nasr, Ali M.

doi:10.22159/ijap.2020v12i1.35312

Cited by 25 publications

(20 citation statements)

References 41 publications

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“…There was a statistically significant difference between pre-and posttest data of depression in the control group, but the control group has not received any education. Nowadays, social media users are increased worldwide [11,12]. Suddenly, in Tamil Nadu, social media users increased.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Effectiveness of Patient Education to Cope Up Depression in Menopausal Stage

Monisha

Doss

et al. 2020

Asian J Pharm Clin Res

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Objectives: The aim of the study was to assess the impact of education to combat depression in the menopausal stage. Methods: Twenty menopausal women, aged 50–55 years were recruited through convenience sampling procedure from Kancheepuram. Zung self-rating depression scale was administered to all the participants. Results: It revealed that there was a statistical difference in post-test after education on depression (t=13.413; p= 0.00) on menopausal women. Conclusion: Depression is the common psychological symptoms that affect the women at menopausal age. The severity is due to a lack of knowledge about the symptoms and a lack of awareness to cope with the psychological symptoms.

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Section: Discussionmentioning

confidence: 99%

Evaluating the Effectiveness of Patient Education to Cope Up Depression in Menopausal Stage

Monisha

Doss

et al. 2020

Asian J Pharm Clin Res

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“…The amount of the non-capsulated drug in the supernatant was estimated spectrophotometrically at 269 nm, utilizing an ultraviolet spectrophotometer (Shimadzu, Yokohama, Japan). Different characterizations such as zeta potential (ZP), particle size as well as the polydispersity index (PDI) of the formulated nanoparticles were measured using a Zetasizer (Malvern Instruments Ltd., Malvern, UK) [ 40 , 41 ], while morphology of the surface of the nanoparticles was confirmed using transmission electron microscopy (TEM) (model JTEM-2100, Tokyo, Japan) [ 42 ]. Release of the drug from different trials was carried out using dialysis bag method [ 43 ] at simulated gastric fluid containing 0.1 N HCl and final pH equalsing 1.2 for 2 h and then substituted with phosphate buffer (pH = 6.8) for the next 10 h. Temperature was kept at 37 ± 1 °C, and drug was assayed spectrophotometrically at 269 nm (UV-visible spectrophotometer, Shimadzu, Yokohama, Japan) [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

Formulation and Characterization of Doxycycline-Loaded Polymeric Nanoparticles for Testing Antitumor/Antiangiogenic Action in Experimental Colon Cancer in Mice

et al. 2022

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Nanotherapeutics can enhance the characteristics of drugs, such as rapid systemic clearance and systemic toxicities. Polymeric nanoparticles (PRNPs) depend on dispersion of a drug in an amorphous state in a polymer matrix. PRNPs are capable of delivering drugs and improving their safety. The primary goal of this study is to formulate doxycycline-loaded PRNPs by applying the nanoprecipitation method. Eudragit S100 (ES100) (for DOX-PRNP1) and hydroxypropyl methyl cellulose phthalate HP55 (for DOX-PRNP2) were tested as the drug carrying polymers and the DOX-PRNP2 showed better characteristics and drug release % and was hence selected to be tested in the biological study. Six different experimental groups were formed from sixty male albino mice. 1,2,-Dimethylhydrazine was used for 16 weeks to induce experimental colon cancer. We compared the oral administration of DOX-PRNP2 in doses of 5 and 10 mg/kg with the free drug. Results indicated that DOX-PRNP2 had greater antitumor activity, as evidenced by an improved histopathological picture for colon specimens as well as a decrease in the tumor scores. In addition, when compared to free DOX, the DOX-PRNP2 reduced the angiogenic indicators VEGD and CD31 to a greater extent. Collectively, the findings demonstrated that formulating DOX in PRNPs was useful in enhancing antitumor activity and can be used in other models of cancers to verify their efficacy and compatibility with our study.

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“…The particle size, zeta potential (ZP), and polydispersity index (PDI) of all prepared DOXY-PNPs were measured using a zeta seizer (Malvern Instruments Ltd., Malvern, UK) [ 69 ]. Each sample of DOXY-PNPs was diluted with distilled water before analysis [ 70 , 71 ].…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

et al. 2020

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Objectives: The aim of this study was to prepare doxycycline polymeric nanoparticles (DOXY-PNPs) with hope to enhance its chemotherapeutic potential against solid Ehrlich carcinoma (SEC). Methods: Three DOXY-PNPs were formulated by nanoprecipitation method using hydroxypropyl methyl cellulose (HPMC) as a polymer. The prepared DOXY-PNPs were evaluated for the encapsulation efficiency (EE%), the drug loading capacity, particle size, zeta potential (ZP) and the in-vitro release for selection of the best formulation. PNP number 3 was selected for further biological testing based on the best pharmaceutical characters. PNP3 (5 and 10 mg/kg) was evaluated for the antitumor potential against SEC grown in female mice by measuring the tumor mass as well as the expression and immunohistochemical staining for the apoptosis markers; caspase 3 and BAX. Results: The biological study documented the greatest reduction in tumor mass in mice treated with PNP3. Importantly, treatment with 5 mg/kg of DOXY-PNPs produced a similar chemotherapeutic effect to that produced by 10 mg/kg of free DOXY. Further, a significant elevation in mRNA expression and immunostaining for caspase 3 and BAX was detected in mice group treated with DOXY-PNPs. Conclusions: The DOXY-PNPs showed greater antitumor potential against SEC grown in mice and greater values for Spearman’s correlation coefficients were detected when correlation with tumor mass or apoptosis markers was examined; this is in comparison to free DOXY. Hence, DOXY-PNPs should be tested in other tumor types to further determine the utility of the current technique in preparing chemotherapeutic agents and enhancing their properties.

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SOLID LIPID NANOPARTICLES (SLNs) AS NANO DRUG DELIVERY CARRIERS: PREPARATION, CHARACTERIZATION AND APPLICATION

Cited by 25 publications

References 41 publications

Evaluating the Effectiveness of Patient Education to Cope Up Depression in Menopausal Stage

Evaluating the Effectiveness of Patient Education to Cope Up Depression in Menopausal Stage

Formulation and Characterization of Doxycycline-Loaded Polymeric Nanoparticles for Testing Antitumor/Antiangiogenic Action in Experimental Colon Cancer in Mice

Synthesis and Antitumor Activity of Doxycycline Polymeric Nanoparticles: Effect on Tumor Apoptosis in Solid Ehrlich Carcinoma

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