Solid Lipid Nanoparticles: Technological Developments and in Vivo Techniques to Evaluate Their Interaction with the Skin

Bleve, Mariella; Pavanetto, F; Perugini, Paola

doi:10.5772/19290

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications 2011

DOI: 10.5772/19290

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Solid Lipid Nanoparticles: Technological Developments and in Vivo Techniques to Evaluate Their Interaction with the Skin

Mariella Bleve¹,

F Pavanetto²,

Paola Perugini³

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2015

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The Use of Solid Lipid Nanoparticles for Sustained Drug Release

Attama

Umeyor

2015

Ther. Deliv.

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Novel solid lipid drug delivery systems such as solid lipid nanoparticles (SLN) have attracted wide and increasing attention in recent years. It has been sought as an interesting alternative drug delivery carrier system for bioactives for a variety of delivery routes. They show major advantages such as sustained release, improved bioavailability, improved drug incorporation and very wide application. This paper presents a discussion on the production protocols of SLN, lyophilization of SLN and delivery of SLN across the blood-brain barrier. Special attention was also paid to entrapment and release of drugs from SLN and strategies to enhance drug entrapment in SLN for sustained release. Analytical methods for the characterization of SLN were also discussed. Various routes of administration of SLN were presented as well as a consideration of the ethical issues and future prospects in the production and use of SLN for sustained release of bioactives.

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The Use of Solid Lipid Nanoparticles for Sustained Drug Release

Attama

Umeyor

2015

Ther. Deliv.

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Solid Lipid Nanoparticles: Technological Developments and in Vivo Techniques to Evaluate Their Interaction with the Skin

Cited by 1 publication

References 88 publications

The Use of Solid Lipid Nanoparticles for Sustained Drug Release

The Use of Solid Lipid Nanoparticles for Sustained Drug Release

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