Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents

Wang, Zihao; Yu, Shaoming; Li, Hongcheng; Liu, Bin; Yan, Xin; Guo, Jianhui

doi:10.1021/acsomega.2c04540

Cited by 7 publications

(5 citation statements)

References 39 publications

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“…The λh model is an empirical formula suitable for the solid−liquid equilibrium system. 35 Its expression is eq 25:…”

Section: λH Modelmentioning

confidence: 99%

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Solubility, Thermodynamic Parameters, and Dissolution Properties of 17-α Hydroxyprogesterone in 13 Pure Solvents

Zhao,

Pan,

Xiong

et al. 2024

ACS Omega

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The static gravimetric method was used to measure the solubility of 17-α hydroxyprogesterone (OHP) in 13 pure solvents ranging from 278.15 to 323.15 K. The results indicate that the experimental solubility of OHP increases with increasing temperature. The experimental solubility data were correlated by the selected van’t Hoff model, λh model, modified Apelblat model, Yaws model, and nonrandom two-liquid (NRTL) model. The fitting results show that the Yaws model can give better correlation results by fitting 13 different pure solvent systems. Based on the NRTL equation, the thermodynamic analysis of solubility data showed that the mixing process was spontaneous. The Hansen solubility parameters (HSPs) and solvent effect were applied to explore these solubility characteristics. Finally, the thermodynamic properties Δsol H°, Δsol S°, Δsol G°, %ξH, and %ξTS were calculated by the van’t Hoff model equation. The results showed that Δsol H°, Δsol S°, and Δsol G° are all positive values, indicating that the dissolution of OHP in the selected solvent is an endothermic reaction with increasing entropy.

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“…The λh model is an empirical formula suitable for the solid−liquid equilibrium system. 35 Its expression is eq 25:…”

Section: λH Modelmentioning

confidence: 99%

“…The λ h model is an empirical formula suitable for the solid–liquid equilibrium system . Its expression is eq : ln [ 1 + λ false( 1 − x 1 false) x 1 ] = λ h true( 1 T − 1 T m ) where λ and h are the model parameters and T m represents the melting point of the OHP.…”

Section: Theoretical Modelsmentioning

confidence: 99%

Solubility, Thermodynamic Parameters, and Dissolution Properties of 17-α Hydroxyprogesterone in 13 Pure Solvents

Zhao,

Pan,

Xiong

et al. 2024

ACS Omega

Self Cite

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“…The modified Apelblat model, derived from the Clausius–Clapeyron equation, is a semiempirical thermodynamic model commonly used to describe the relationships between the molar solubility of the solute and its temperature. , The equation can be described as follows ln nobreak0em0.25em⁡ x 1 = A 1 + B 1 T + C 1 0.25em ln ( T ) …”

Section: Calculation Modelsmentioning

confidence: 99%

Thermodynamic Analysis of Eplerenone in 13 Pure Solvents at Temperatures from 283.15 to 323.15 K

Liu,

Zhang

et al. 2024

ACS Omega

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The solubility of eplerenone (EP) in 13 pure solvents (acetonitrile, N,N-dimethylformamide (DMF), acetone, 2-butanone, 4-methyl-2-pentanone, ethyl formate, methyl acetate, ethyl acetate, propyl acetate, butyl acetate, methyl propionate, ethyl propionate, ethanol, and 1-propanol) was determined by the gravimetric method at atmospheric pressure and various temperatures (from 283.15 to 323.15 K). The results showed that the solubility of EP in the selected solvents was positively correlated with the thermodynamic temperature, and the order of solubility of EP at 298.15 K was acetonitrile > DMF > 2-butanone > methyl acetate > 4-methyl-2pentanone > methyl propionate > ethyl acetate > propyl acetate > ethyl formate > acetone > butyl acetate > ethanol >1-propanol. The modified Apelblat model, van't Hoff model, λh model, and polynomial empirical model were used for fitting the solubility data, and then the λh model was found to have the highest fitting accuracy with a minimum ARD of 7.0 × 10 −3 and a minimum RMSD of 6.1 × 10 −6 . The solvent effect between the solute and the solvent was analyzed using linear solvation energy relationship (LSER), and the enthalpy of solvation (Δ sol H°), entropy of solvation (Δ sol S°), and Gibbs free energy of solvation (Δ sol G°) of the dissolution process of EP were calculated by the van't Hoff model, which indicated that the dissolution process of EP in the selected solvents was endothermic, nonspontaneous, and entropyincreasing. In this work, the solubility, dissolution characteristics, and thermodynamic parameters of EP were studied, which will provide data support for the production, crystallization, and purification of EP and will provide important guidance for the crystallization optimization of EP in industry.

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“…The λh model 23 proposed by Buchowski and Ksiazaczak, which is widely used, has two parameters, namely, λ and h. These parameters were measured and are listed in Table 3. The mathematical representation of this model is i k j j j j j y…”

Section: λH Modelmentioning

confidence: 99%

Solubility and Thermodynamics Profile of Benzethonium Chloride in Pure and Binary Solvents at Different Temperatures

et al. 2023

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Benzethonium chloride (BTC) has various applications in several industries. The solubility and solution thermodynamic properties of BTC were measured. The solubility of BTC in methanol, ethanol, 1-propanol, 2-propanol, 1butanol, water, dimethyl sulfoxide, acetic acid, and dimethyl formamide neat solvents and methanol + water and ethanol + water binary solvents at 298.15−318.15 K over an atmospheric pressure was measured. The solubility data of BTC is positively related to the temperature in all selected solvents. The solubility data was fitted by the Apelblat model, λh model, Yaws model, Van't Hoff equation, CNIBS/R-K model, and modified Jouyban−Acree equation. The RMSD and ARD were chosen to evaluate the fitting of each model. The dissolution thermodynamic parameters, enthalpy of the solution, entropy of the solution, and Gibbs energy of the solution were calculated. The solubility data and dissolution thermodynamic parameters of BTC will provide significant guidance for purification, crystallization, and separation in various areas.

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Solid–Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents

Cited by 7 publications

References 39 publications

Solubility, Thermodynamic Parameters, and Dissolution Properties of 17-α Hydroxyprogesterone in 13 Pure Solvents

Solubility, Thermodynamic Parameters, and Dissolution Properties of 17-α Hydroxyprogesterone in 13 Pure Solvents

Thermodynamic Analysis of Eplerenone in 13 Pure Solvents at Temperatures from 283.15 to 323.15 K

Solubility and Thermodynamics Profile of Benzethonium Chloride in Pure and Binary Solvents at Different Temperatures

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