Solid–liquid equilibrium of azithromycin in water+1,2-propanediol solutions from (289.35 to 319.15) K

Liu, Mengjiao; Yin, Dai-ping; Fu, Hualin; Liu, Mengxi; Zhou, Jianyu; Qing, Xue-yan; Wu, Wenbin

doi:10.1016/j.molliq.2014.08.016

Cited by 10 publications

(7 citation statements)

References 16 publications

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“…Our method has been reported many times to include the work of Feng et al and Shao et al Besides, the solubility measurements were repeated three times at each temperature in order to obtain a required mean value. In addition, the method for the solubility measurement has been used in our previous work and obtained accurate data . Therefore, we are sure that our values are acceptable.…”

Section: Results and Discussionmentioning

confidence: 63%

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Solubility of Trimethoprim in Selected Pure Solvents and (Water + Ethanol/2-Propanol) Mixed-Solvent Systems

Yin

Liu

et al. 2015

J. Chem. Eng. Data

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Trimethoprim (TMP) is an important antibacterial synergist in human and veterinary medicine. In this work, the solubilities of TMP in five pure solvents (ethanol, water, ethyl acetate, acetonitrile, and 2-propanol) and two binary mixtures (ethanol + water and 2-propanol + water) were measured by an equilibrium method over the temperature range from (293.15 to 322.65) K under atmospheric pressure. The experimental results show that in the pure solvents the solubility of TMP increases with increasing temperature, and the solubility decreases in the following order: ethanol > acetonitrile > 2-propanol > ethyl acetate > water. In the mixed solvents, the solubility of TMP increases with increasing temperature and mass fraction of the organic solvent. The mole-fraction solubility of TMP was observed to be the highest in the mixed solvent 50% ethanol/2-propanol, and the lowest mole-fraction solubility of TMP was found in water. Three correlating models (the modified Apelblat equation, the λh equation, and the ideal model) were used to correlate the experimental solubility values in the pure solvents, and four models (the modified Apelblat equation, the λh equation, the ideal model, and the CNIBS/R-K model) were applied to correlate the experimental solubilities in the mixed solvents. All of these thermodynamic models gave satisfactory correlation results, with the modified Apelblat equation showing better fitting degree than the other three equations. Furthermore, the standard molar enthalpy of the TMP during the dissolving process (ΔH sol °) was also determined in this work, and the results show that the dissolution process is endothermic.

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Section: Results and Discussionmentioning

confidence: 63%

“…In addition, the method for the solubility measurement has been used in our previous work and obtained accurate data. 22 Therefore, we are sure that our values are acceptable.…”

Section: Resultsmentioning

confidence: 83%

Solubility of Trimethoprim in Selected Pure Solvents and (Water + Ethanol/2-Propanol) Mixed-Solvent Systems

Yin

Liu

et al. 2015

J. Chem. Eng. Data

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“…As an informational note, this is not the first time that members of this research group have reported equation coefficients based on eq that predict solute mole fraction solubilities in the organic cosolvent that exceed unity. Published equation coefficients for azithromycin in binary water + 1,2-propanediol solvent mixtures predict a value of x 1 = exp (5925.1) at 289.35 K in 1,2-propanediol …”

mentioning

confidence: 99%

“…Published equation coefficients for azithromycin in binary water + 1,2-propanediol solvent mixtures predict a value of x 1 = exp (5925.1) at 289.35 K in 1,2-propanediol. 5 We suspect that the reason for why the authors' calculated equation coefficients fail to accurately describe the measured TMP solubility data in both ethanol and 2-propanol arises because the authors failed to include the experimental solubility data for TMP in the two organic cosolvents in their regression analysis. This would be an extremely serious curve-fitting mistake.…”

mentioning

confidence: 99%

Comment on “Solubility of Trimethoprim in Selected Pure Solvents and (Water + Ethanol/2-Propanol) Mixed-Solvent Systems”

Acree

Jouyban²,

Martínez³

2017

J. Chem. Eng. Data

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Mathematical representations reported by Yin and co-workers for the Combined Nearly Ideal Binary Solvent (NIBS)/Redlich–Kister model are carefully examined in regards to the model’s ability to predict the solubility of trimethoprim dissolved in binary aqueous-2-propanol and aqueous-ethanol solvent mixtures. The equation coefficients reported by Yin and co-workers were found to give calculated mole fraction solubilities in the two alcohol monosolvents that exceed unity. The narrow range of solvent composition over which the authors performed solubility measurements does not enable one to derive mathematical correlations for predicting the solubility of trimethoprim in the alcohol-rich solvent composition region.

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“…The models are commonly used in the chemical and pharmaceutical industries. In the past two years there have been several incorrect applications ,− of the models that have led to calculated mole fraction solubilities that have exceeded unity in one or both of the monosolvents used to prepare the binary solvent mixture. Several of the incorrect applications ,, have involved solubility studies in which the authors performed experimental measurements in a very narrow range of binary solvent composition.…”

mentioning

confidence: 99%

Comment on “Measurement and Correlation of the Solubility of Maltitol in Different Pure Solvents, Methanol–Water Mixtures, and Ethanol–Water Mixtures”

2017

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Mathematical representations reported by Li et al. for a number of cosolvency models are carefully examined concerning the models' abilities to predict the solubility of maltitol in binary aqueous mixtures of methanol and ethanol at various temperatures. Some further recommendations on computational methods are also provided to be employed in the future research works. Preferential solvation of the solution was also investigated to provide better understanding of the dissolution process.

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Solid–liquid equilibrium of azithromycin in water+1,2-propanediol solutions from (289.35 to 319.15) K

Cited by 10 publications

References 16 publications

Solubility of Trimethoprim in Selected Pure Solvents and (Water + Ethanol/2-Propanol) Mixed-Solvent Systems

Solubility of Trimethoprim in Selected Pure Solvents and (Water + Ethanol/2-Propanol) Mixed-Solvent Systems

Comment on “Solubility of Trimethoprim in Selected Pure Solvents and (Water + Ethanol/2-Propanol) Mixed-Solvent Systems”

Comment on “Measurement and Correlation of the Solubility of Maltitol in Different Pure Solvents, Methanol–Water Mixtures, and Ethanol–Water Mixtures”

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