Solid–Liquid Equilibrium of Chlorpropamide in 14 Pure Solvents at Temperature of 283.15 to 323.15 K

Abstract

In this paper, the solubility of chlorpropamide (CPA) in 14 solvents including 8 alcohols (ethanol, n-propanol, isopropanol, n-butanol, 2-butanol, iso-butanol, n-pentanol, and isopentanol) and 6 acetate esters (ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, amyl acetate, and methyl propionate) at temperatures of 283.15 to 323.15 K and atmospheric pressure was determined using a laser method. The solubility as a function of temperature was regressed using modified Apelblat, Van’t Hoff, λh, Wilson, and nonrandom two-liquid (NRTL) models. On the basis of the experimental and the simulation results, the mixing properties of the solutions, that is, mixing Gibbs energy, enthalpy, and entropy, were estimated.

Solubility and Model Correlation of Doxofylline in Pure Solvents at the Temperature Range of 283.15–323.15 K

“…In a binary dissolution system, the Wilson model can be used to calculate the activity coefficient of the solute, which is described as shown by eqs –. , where λ 12 , λ 21 , a 12 , b 12 , a 21 , and b 21 are the interaction parameters and V 1 and V 2 are the molar volumes of solute and solvent, respectively.…”

“…It was proposed by Renon and Prausnitz based on Wilson’s local composition concept and Scott’s two-fluid model. The NRTL equation is shown by eqs –. ,, where α is the measure of the nonrandomness of the mixture (range from 0.2 to 0.47). In this paper, it is taken as 0.2, and g ij , a ij , and b ij ( I = 1,2; j = 1,2) are the interaction parameters.…”

“…Based on the experimental solubility data and the parameters of the Wilson model, the excess mixing properties can be evaluated by eqs – ,, The activity coefficient (γ 1 ∞ ) and the reduced excess enthalpy ( H 1 E,∞ ) at infinitesimal concentration can be shown as eqs and . , Based on the experimental data in Table and the parameter values of the Wilson model in Table , Δ mix G , Δ mix H , Δ mix S , ln­(γ 1 ∞ ), and H 1 E,∞ are evaluated and listed in Table . The mixing Gibbs energy (Δ mix G ) of DFL in different solvents as a function of the temperature is given in Figure .…”

“…In a binary dissolution system, the Wilson model can be used to calculate the activity coefficient of the solute, which is described as shown by eqs 6−8. 26,27 Ä…”

“…) and the reduced excess enthalpy (H 1 E,∞ ) at infinitesimal concentration can be shown as eqs 21 and 22. 26,27 ln( ) ln 1…”