Solid-liquid equilibrium solubility, thermodynamic properties, and solvent effect of flavoxate hydrochloride in twelve pure solvents ranged from 278.15 K to 323.15 K

Fan, Di; Cao, Zidan; Liu, Yu; Li, Tao; Ren, Baozeng

doi:10.1016/j.jct.2022.106985

Cited by 6 publications

(1 citation statement)

References 31 publications

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“…The relative contributions of Δ dis H 0 and Δ dis S 0 to the PDAH dissolution process were calculated by eqs and % .25em δ H = false| normalΔ d i s H 0 false| | Δ normald normali normals H ° | + | T normalm normale normala normaln Δ normald normali normals S 0 | × 100 % .25em δ S = false| normalΔ d i s S 0 false| | Δ normald normali normals H 0 | + | T normalm normale normala normaln Δ normald normali normals S 0 | × 100 where % δ H and % δ s are the contribution of enthalpy and entropy to Δ dis G 0 , respectively.…”

Section: Resultsmentioning

confidence: 99%

Thermodynamics, Solubility, and Crystallization of 1,5-Pentylenediamine Hydrochloride in Mixed Solvent Systems

Li,

Hu,

et al. 2024

Ind. Eng. Chem. Res.

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The properties of 1,5-pentylenediamine hydrochloride (PDAH), a precursor of biobased pentamethylene diisocyanate (PDI), have a key influence on the PDI quality. In this study, the thermodynamics, solubility, and crystallization of PDAH in ethanol−water mixed solutions (0−100 wt % ethanol) were investigated. First, the solubility was investigated at 273.15− 323.15 K by a solvent evaporation method and characterized using the Apelblat, polynomial empirical, λh, and the modified van't Hoff−Jouyban−Acree equations. The activity coefficient increased with decreasing polarity and decreasing temperature. Thermodynamic analysis shows that dissolution is always spontaneous if the solution is not saturated. The surface tension and surface entropy factor increased with decreasing polarity and decreasing temperature. Finally, the crystallization of PDAH in an ethanol−water solution was studied by comparing cooling crystallization, antisolvent crystallization, and three combined cooling and antisolvent crystallization processes. The best crystallization process was found to be antisolvent, followed by cooling crystallization, with a 66.72% one-time yield and 99% purity. This study provides an important reference for the crystallization separation of other biobased products.

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