Solid–liquid phase equilibria in binary systems with paracetamol

Leitner, J.; Horníková, K.; Studničková, N.; Sedmidubský, David

doi:10.1007/s10973-022-11533-y

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…Leitner and Jurik 22 and Kouskováand Leitner 23 investigated SLE in the paracetamol−o-acetylsalicylic acid and o-acetylsalicylic acid−caffeine binary systems. Leitner et al 24 studied SLE in three binary systems containing paracetamol, with phenylephrine hydrochloride, tramadol hydrochloride, and ibuprofen, respectively. Soare et al 25 reported SLE data for the binary systems of ibuprofendrotaverine hydrochloride and ketoprofen-drotaverine hydrochloride.…”

Section: Introductionmentioning

confidence: 99%

Measurements of Binary Solid–Liquid Equilibrium of Anticancer Drug p-Toluenesulfonamide with Benzamide, Isonicotinamide, or Salicylamide

Chen,

Khudaida,

2024

J. Chem. Eng. Data

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Understanding the solid–liquid equilibrium (SLE) of active pharmaceutical ingredients (APIs) with excipients or other synergistic APIs is crucial for drug design and development. In this study, a poorly water-soluble anticancer API, p-toluenesulfonamide, was chosen as the model compound. SLE data and the eutectic conditions for three binary mixtures, p-toluenesulfonamide (1) + benzamide (2) (T E = 354.2 K, x 1E = 0.453); p-toluenesulfonamide (1) + isonicotinamide (2) (T E = 368.4 K, x 1E = 0.510); p-toluenesulfonamide (1) + salicylamide (2) (T E = 371.7 K, x 1E = 0.538), were measured and reported using the differential scanning calorimetry (DSC) method. Simple eutectic behaviors were observed in these systems, with the eutectic and liquidus temperatures presented for each binary mixture at various compositions. The experimental eutectic composition was identified based on Tammann plots using the enthalpy values obtained from DSC measurements. Subsequently, the experimental liquidus temperatures were correlated using the Wilson and nonrandom two-liquid (NRTL) activity coefficient models, yielding the average absolute deviation in temperature (AADT) of less than 0.6%. These new SLE data provide valuable information for designing and developing drug formulations of p-toluenesulfonamide, thereby exploring potential applications.

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Section: Introductionmentioning

confidence: 99%

Measurements of Binary Solid–Liquid Equilibrium of Anticancer Drug p-Toluenesulfonamide with Benzamide, Isonicotinamide, or Salicylamide

Chen,

Khudaida,

2024

J. Chem. Eng. Data

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Quantum Chemistry and Pharmacy: Diagnostic Check of the Thermochemistry of Ibuprofen

Emel'yanenko,

Zherikova,

Verevkin

2024

ChemPhysChem

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The thermodynamic data on ibuprofen available in the literature shows that the disarray of experimental results is unacceptable for this very important drug. The data on ibuprofens available in the literature were collected, combined with our complementary experimental results and evaluated. The enthalpies of combustion and formation of the crystalline RS‐(±)‐ and S‐(+)‐ibuprofens were measured using high‐precision combustion calorimetry. The temperature dependence of the vapour pressure of S‐(+)‐ibuprofen was measured using the transpiration method and the enthalpy of vaporisation was derived from this measurement. The enthalpies of fusion of both compounds were measured using DSC. The G4 calculations have been carried out to determine the enthalpy of formation in gaseous state of the most stable conformer. Thermochemical properties of studied compounds were evaluated and tested for consistency with the “centerpiece approach”. A set of reliable and consistent values of thermodynamic properties of ibuprofens at 298.15 К was recommended for thermochemical calculations of the pharmaceutic processes. The diagnostic protocol was developed to distinguish the “sick” or “healthy” thermodynamic data. This diagnostic is also applicable to other drugs with a different structure than ibuprofen.

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Experimental Data and Thermodynamic Modeling of Solid–Liquid and Liquid–Vapor Equilibria in the CO2 + Ethanol + Acetaminophen System

Mattos,

Molina,

Rodriguez-Reartes

et al. 2024

Russ. J. Phys. Chem.

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Solid–liquid phase equilibria in binary systems with paracetamol

Cited by 3 publications

References 55 publications

Measurements of Binary Solid–Liquid Equilibrium of Anticancer Drug p-Toluenesulfonamide with Benzamide, Isonicotinamide, or Salicylamide

Measurements of Binary Solid–Liquid Equilibrium of Anticancer Drug p-Toluenesulfonamide with Benzamide, Isonicotinamide, or Salicylamide

Quantum Chemistry and Pharmacy: Diagnostic Check of the Thermochemistry of Ibuprofen

Experimental Data and Thermodynamic Modeling of Solid–Liquid and Liquid–Vapor Equilibria in the CO2 + Ethanol + Acetaminophen System

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